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Stephen Harris, Ph.D.
Dental School
Periodontics
210-567-3723
harris@uthscsa.edu
Bone and Periodontal stem cells, epigenomica, lineage tracing, and conditional KO studies in mice with the Bmp2 and Sost genes Research
Sub-Field of Study: Bioinformatics with specialty in epigenomics and transcriptomics
Techniques Used: conditional ko studies, with uct, sem, high resolution x-rays, histology, rna-seq analysis with the Alamo supercomputer, confocal and image analysis
Education
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| Year | Degree | Discipline | Institution |
| 1969 | PhD | Biochemical Embryology | University of Texas Austin , TX |
| 1969 | PhD | Biochemical Embryology | University of Texas Austin , TX |
| 1966 | MA | Biochemical Genetics | University of Texas Austin , TX |
| 1966 | MA | Biochemical Genetics | University of Texas Austin , TX |
| 1965 | BA | Zoology | University of Texas Austin , TX |
| 1965 | BA | Zoology | University of Texas Austin , TX |
| Postdoctoral Fellowship | California Institute of Technology Pasadena , CA |
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| Postdoctoral Fellowship | California Institute of Technology Pasadena , CA |
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| Residency | Vanderbilt University School of Medicine Nashville , TN |
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| Residency | Vanderbilt University School of Medicine Nashville , TN |
Appointments
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| 1/2004 - Present | Professor | University of Texas Health Science Center at San Antonio, Cellular & Structural Biology, San Antonio, TX |
| 1/2004 - Present | Professor and Director of Research | University of Texas Heatlh Science Center at San Antonio, Periodontics, San Antonio, TX |
| 1/2004 - Present | Professor and Director of Research | University of Texas Heatlh Science Center at San Antonio, Periodontics, San Antonio, TX |
| 1/2004 - Present | Professor | University of Texas Health Science Center at San Antonio, Cellular & Structural Biology, San Antonio, TX |
Expertise
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BMP2 Mechansisms - Mechanisms of how BMP2 instructs cells to new differentiated functions during development and during bone and teeth formation. |
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BMP2 Mechansisms - Mechanisms of how BMP2 instructs cells to new differentiated functions during development and during bone and teeth formation. |
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Bone Morphogenetic Protein (BMP) Genes - Structure and functional analysis of bone morphogenetic protein (BMP) genes with focus on BMP2 and BMP4 genes. Develop condition knock-out of both BMP2 and BMP4 in osteoblasts using the Cre-loxP system and Tamoxifen temporal control of Cre activity. |
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Bone Morphogenetic Protein (BMP) Genes - Structure and functional analysis of bone morphogenetic protein (BMP) genes with focus on BMP2 and BMP4 genes. Develop condition knock-out of both BMP2 and BMP4 in osteoblasts using the Cre-loxP system and Tamoxifen temporal control of Cre activity. |
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Osteocyte Function - Analysis of osteocyte function in vitro and in vivo after mechanical loading. Genomic analysis of osteocyte gene expression signatures and gene regulatory networks. Cis regulatory analysis of osteocyte and mechanically responsive genes using BAC recombineering. |
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Osteocyte Function - Analysis of osteocyte function in vitro and in vivo after mechanical loading. Genomic analysis of osteocyte gene expression signatures and gene regulatory networks. Cis regulatory analysis of osteocyte and mechanically responsive genes using BAC recombineering. |
Publications
Journal Article |
| Prideaux M, Dallas SL, Zhao N, Johnsrud ED, Veno PA, Guo D, Mishina Y, Harris SE, Bonewald LF. Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms PLoS One 2015 May;10(5):0125731-0125731. |
| Prideaux M, Dallas SL, Zhao N, Johnsrud ED, Veno PA, Guo D, Mishina Y, Harris SE, Bonewald LF. Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms PLoS One 2015 May;10(5):0125731-0125731. |
| Yang W, Guo D, Harris MA, Cui Y, Gluhak-Heinrich J, Wu J, Chen XD, Skinner C, Nyman JS, Edwards JR, Mundy GR, Lichtler A, Kream BE, Rowe DW, Kalajzic I, David V, Quarles DL, Villareal D, Scott G, Ray M, Liu S, Martin JF, Mishina Y, Harris SE. Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells J Cell Sci 2013 Sep;126:4085-4098. |
| Yang W, Guo D, Harris MA, Cui Y, Gluhak-Heinrich J, Wu J, Chen XD, Skinner C, Nyman JS, Edwards JR, Mundy GR, Lichtler A, Kream BE, Rowe DW, Kalajzic I, David V, Quarles DL, Villareal D, Scott G, Ray M, Liu S, Martin JF, Mishina Y, Harris SE. Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells J Cell Sci 2013 Sep;126:4085-4098. |
| Rakian A, Yang WC, Gluhak-Heinrich J, Cui Y, Harris MA, Villarreal D, Feng JQ, Macdougall M, Harris SE. Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium Int J Oral Sci 2013 Jun;5(2):75-84. |
| Rakian A, Yang WC, Gluhak-Heinrich J, Cui Y, Harris MA, Villarreal D, Feng JQ, Macdougall M, Harris SE. Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium Int J Oral Sci 2013 Jun;5(2):75-84. |
Teaching
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| Date | Description | Institution | # Students |
| 1/2007 - Present | Bone & Connective Tissue Biology | The University of Texas Health Science Center | 12 students |
| Course Director | |||
| 1/2007 - Present | Bone & Connective Tissue Biology | The University of Texas Health Science Center | 12 students |
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| 8/2006 - Present | Ph.D. Dissertations Directed | University of Texas Health Science Center at San Antonio | |
| 8/2006 - Present | Ph.D. Dissertations Directed | University of Texas Health Science Center at San Antonio | |
| 8/2005 - Present | Ph.D. Dissertations Directed | University of Texas Health Science Center at San Antonio and University of Texas at San Antonio | |
| 8/2005 - Present | Ph.D. Dissertations Directed | University of Texas Health Science Center at San Antonio and University of Texas at San Antonio | |