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Asma Khan, Ph.D., B.D.S.
Dental School
Endodontics
210-567-3381
khana2@uthscsa.edu
Dr. Khan is an endodontist and a neuroscientist. She conducts clinical, translational and basic science research towards the ultimate goal of improving pain management. Her current clinical projects are on the (1) development of new strategies for the diagnosis and management of acute odontogenic pain, (2) evaluation of new analgesics and anesthetics and (3) development of new diagnostics for the detection of cracks in teeth. Translational and basic science projects are focused on the role of extracellular vesicles (aka exosomes) and microRNAs in pain. The aim of these projects is to elucidate the mechanisms by which extracellular vesicles and microRNAs modulate pain.
Dr. Khan enjoys mentoring students. She teaches both pre-doctoral and graduate students. She also enjoys treating patients and maintains a private endodontic practice.
Research Interests:
- Development of new diagnostics Extracellular Vesicles (Exosomes)
- Pain
- microRNAs
- Analgesics
- Anesthetics
Education
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| Year | Degree | Discipline | Institution |
| 2006 | Postdoctoral Fellowship | Pain | University of Texas Health Science Center at San Antonio San Antonio , TX |
| 2006 | Certificate | Endodontics | University of Texas Health Science Center at San Antonio San Antonio , TX |
| 2003 | Postdoctoral Fellowship | Craniofacial Oral-Biology | University of Texas Health Science Center at San Antonio San Antonio , TX |
| 2002 | PhD | Neuroscience | University of Maryland, Dental School Baltimore , MD |
| 2002 | Clinical Fellowship | Clinical Research Fellowship | National Institute of Dental and Craniofaical Research, NIH |
| 1995 | BDS | Dentistry | Gulbarga University India |
| 1995 | Internship | General Dentistry | Government Dental College and Hospital Hyderabad , India |
Appointments
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| 1/2014 - Present | Associate Professor with tenure | University of North Carolina at Chapel Hill, Endodontics, Chapel Hill, NC |
| 1/2008 - Present | Adjunct Assistant Professor | University of Texas Health Science Center at San Antonio, Endodontics, San Antonio, TX |
Expertise
| Analgesics |
| Anesthetics |
| Current Research Projects - Current research projects include clinical research, translational and basic science research. Clinical projects are on the (1) development of new strategies for the diagnosis and management of acute odontogenic pain, (2) evaluation of new analgesics and anesthetics and, (3) development of new diagnostics for the detection of cracks in teeth. Translational and basic science research projects are focused on the role of extracellular vesicles and microRNAs in pain. The aim is to elucidate the mechanisms by which extracellular vesicles and microRNAs modulate pain. |
| Development of New Diagnostics |
| Extracellular Vesicle |
| Pain |
| microRNAs |
Publications
Abstract |
| Pluta L, Babak Y, Convertino M, Khan A. Endosomal TLR8 Senses microRNA-1294 Inducing the Release of NF?EB-Dependent Cytokines; 2018 Jan. (IADR). |
| Mittelsteadt M, Khan A. Presence of Cotton Fibers on Disinfected Gutta Percha Cones; 2018 Jan. (AAE). |
| Fox D, Park G, Mora M, Casey S, Duong W, Flake NM, Khan A, Gibbs J. Clinical and Radiographic Outcomes of Regenerative Endodontic Procedures; 2018 Jan. (AADR). |
| Le A, Casey S, Fox D, Flake NM, Khan A, Gibbs J. Predictability of continued root development of regenerative Endodontic Procedures; 2018 Jan. (AADR). |
| Shah H, Hernandez P, Budin F, Chittajallu D, Vimort JB, Walters R, Mol A, Khan A. Paniagua B. Automatic quantification framework to detect cracks in teeth; 2018 Jan. (SPIE Int Soc Opt Eng). |
| Convertina M, Dokhloyan N, Maixner M, Khan A. Structural basis underlying the interaction between miRNAs and TLR8; 2017 Jan. (American Pain Society). |
| Duong W, Bui N, Casey S, Khan A, Flake N, Gibbs J. Patient and Treatment Factors Associated with Clinically Successful Regenerative Endodontic Procedures; 2017 Jan. (J Endod; vol. 43, no. 3). |
| Yeung W, Shallal_Ayzin M, Trinh T, Tawil P, Haggerty C, Wu D, Khan A. Prospective Analysis of Prognostic Indicators of Direct Pulp Caps on Mature Permanent Teeth; 2017 Jan. (J Endod; vol. 43, no. 3). |
| Shallal-Ayzin M, Yeung W, Trinh T, Tawil P, Haggerty C, Wu D, Khan A. Prospective Analysis of Perioperative Pain Following VPT on Permanent Teeth with Mature Apices; 2017 Jan. (J Endod; vol. 43, no. 3). |
| Trinh T, Shallal-Ayzin M, Yeung W, Tawil P, Haggerty C, Wu D, Khan A. The Influence of Intra-Operative Factors on Vital Pulp Therapy Outcome; 2017 Jan. (J Endod; vol. 43, no. 3). |
| Zahran S, Peters O, Yu R, Chino T, Khan A, Galicia J. Characterization of Human Cytokine Biomarkers in the Gingival Crevicular Fluid; 2017 Jan. (J Endod; vol. 43, no. 3). |
| Bui N, Casey S, Sigurdsson A, Flake N, Khan A, Gibbs J. Clinical Assessment of Success and Failure after Regenerative Endodontic Procedures; 2017 Jan. (J Endod; vol. 43, no. 3). |
| Vera C, LaPrade C, Bair E, Hicks M, Albury T, Salo P, Khan A, Cooper L, Maixner W. Dental Implants: Assessments of Pain Discomfort and Altered Sensations; 2016 Jan. (IASP). |
| Galicia JC, Henson BR, Parker JS, Khan A. Gene expression Profile of Pulpitis; 2016 Jan. (IADR). |
| St Paul A, Phillips C, Lee J, Gouveia K, Khan A. Provider Perceptions of Treatment Options for Immature Permanent Teeth; 2016 Jan. (J Endod; vol. 45, no. 3). |
| Tagger T, Wu D, Khan A. The Analgesic Effect of a New Ibuprofen Formulation on Odontogenic Pain; 2016 Jan. (J Endod; vol. 45, no. 3). |
| Latifi N, Ramesh V, Casey S, Saadatisohi A, Podborits E, Sigurdsson A, Flake N, Khan A, Gibbs J. Clinical Outcomes of Endodontic Treatment in Children with Immature Permanent Teeth: An Interim Analysis; 2016 Jan. (J Endod; vol. 5, no. 3). |
| Jacobsen C, Kim A, Luu M, Khan A, Gibbs J, Flake N. Retrospective Study of Radiographic Outcomes of Endodontic Treatment of Immature Teeth with Necrotic Pulps; 2016 Jan. (J Endod; vol. 45, no. 3). |
| Zhong S, Naqvi A, Bair E, Nares S, Khan A. Viral microRNAs: New Players in Endodontic Disease?; 2016 Jan. (J Endod; vol. 45, no. 3). |
| Galicia J, Henson B, Parker J, Khan A. Genetic signature of Pulpitis; 2015 Jan. (J Endod; vol. 41). |
| Coston C, Misra A, Podborits E, Luu M, Flake N, Khan A, Gibbs J. A Multi-Centered Retrospective Evaluation of Clinical and Radiographic Outcomes of Revascularization /Revitalization Therapy in Immature Teeth; Study Design and Recruitment; 2015 Jan. (J Endod; vol. 41). |
| Mitchel B, Tyndall D, Frazier-Bowen S, Khan A. Making the Invisible Visible: A New Diagnostic Tool in Endodontics; 2015 Jan. (J Endod; vol. 41). |
| Luu M, Kim A, Gibbs J, Khan A, Flake N. Patient Compliance with Endodontic Treatment of Immature Necrotic Permanent Teeth; 2015 Jan. (J Endod; vol. 41). |
| Henson B, Khan A, Parker J, Galicia J. Age Related Gene Expression Differences in Human Dental Pulp; 2015 Jan. (IADR). |
| Galicia J, Naqvi AR, Ko C, Nares S, Khan A. miRNA181a Negatively Regulates Toll-Like Receptor Agonist-Induced Interleukin-8 Production in Human Dental Pulp Fibroblasts and Macrophages; 2014 Jan. (J Endod; vol. 40, no. 3). |
| Hosseini B, Byrd WC, Khan A, Duggan, Bencharit S. Antibiotics and Immediate Implant Therapy for Teeth with Apical Pathology; 2014 Jan. (IADR). |
Book Chapter |
| Ruparel N, Khan A. Dental Innervation and Pain of Pulpal Origin. In: Ingle J, Rotstein, I, eds. Ingle?s Endodontics. USA: People Medical Publishing House; 2018. |
| Khan A. Otolaryngology Essentials for Primary Care: A Guide to the Head and Neck for the Physician and Physician Assistant. In: Gunn JF, Dutra JC, Micco AG, eds. Orofacial pain. Arlington, MA: In Press Publication; 2016. |
| Reader A, Nusstein J, Khan A. Pain Control. In: Hargreaves KM, Cohen S, eds. Pathways of the Pulp 11th ed. St Louis, MO: Mosby Elsevier; 2015. |
Journal Article |
| Dionne RA, Warburton G, Khan A. When are Opioids indicated for Post-operative Analgesia in Dental Practice Compendium of Continuing Education in Dentistry 2018 Jan;39. |
| Duqum I, Barker S, Marshall E, Wang R, Preisser JS, Khan A. The effect of single tooth implant restorations on the survival morbidity, pulp and periapical health of adjacent teeth- a chart review Clinical Implant Dentistry and Related Research 2018 Jan;20:479-482. |
| Shah H, Hernandez P, Budin F, Chittajallu D, Vimort JB, Walters R, Mol A, Khan A. Automatic quantification framework to detect cracks in teeth SPIE Int Soc Opt Eng 2018 Jan;. |
| St Paul H, Phillips C, Lee J, Khan A. Provider Perceptions of Treatment Options for Immature Permanent Teeth J Endod 2017 Jan;43:910-915. |
| Tagger TJ, Wu D, Khan A. A randomized clinical trial comparing two ibuprofen formulations in patients with acute odontogenic pain J Endod 2017 Jan;43:674-678. |
| Zhong S, Naqvi SR, Nares S, Bair E, Khan A. Viral microRNAs Identified in Human Dental Pulp J Endod 2017 Jan;43:84-89. |
| Naqvi SR, Zhong S, Dang H, Fordham JB, Nares S, Khan A. Expression profiling of LPS responsive miRNA in Primary Human Macrophages J Microb Biochem Technol 2016 Jan;8:136-143. |
| Galicia J, Henson BR, Parker JS, Khan A. Gene expression profile of pulpitis Genes Immun 2016 Jan;17:239-243. |
| Ciszek BP, Khan A, Dang H, Slade DS, Smith S, Bair E, Maixner W, Zolnoun D, Nackley AG. MicroRNA Expression Profiles Differentiate Chronic Pain Condition Subtypes Transl Res 2015 Jan;166(6):706-720. |
| Applebaum E, Nackley AG, Bair E, Khan A. Genetic Variants in Cyclooxygenase Contribute to Post-Treatment Pain among Endodontic Patients J Endod 2015 Jan;41:1214-1218. |
| Aminoshariae A, Khan A. Acetaminophen: Old drug, New Issues J Endod 2015 Jan;41:588-593. |
| Hosseini B, Byrd WC, Preisser JS, Khan A, Duggan D, Bencharit S. Effects of Antibiotics on Bone and Soft Tissue Healing Following Immediate Single-tooth Implant Placement into Sites with Apical Pathology J Oral Implantol 2015 Jan;41(5):e202-e211. |
| Naqvi AR, Fordham JB, Khan A, Nares S. MicroRNAs responsive to Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis LPS modulate expression of genes regulating innate immunity in human macrophages Innate Immun 2014 Jul;20(5):50-551. |
| Read JK, Bowles WR, Khan A, Lunos S, McClanahan S. Effect of Ibuprofen on Masking Endodontic Diagnosis: A Randomized Clinical Trial J Endod 2014 Jan;40:1058-1062. |
| Galicia J, Naqvi AR, Ko C, Nares S, Khan A. miRNA181a Negatively Regulates Toll-Like Receptor Agonist-Induced Interleukin-8 Production in Human Dental Pulp Fibroblasts and Macrophages Genes and Immunity 2014 Jan;15:333-337. |
| Flake NM, Gibbs JL, Diogenes A, Hargreaves KM, Khan A. A standardized novel method to evaluate radiographic root changes following endodontic therapy in immature teeth J Endod 2014 Jan;40:46-50. |
| Lim PF, Maixner W, Khan A. Persistent Pain following Endodontic Therapy JADA 2014 Jan;145:270-272. |
| Richardson SL, Khan A, Rivera EM, Phillips C. Access to Endodontic Care in North Carolina Public Health and Medicaid Settings J Public Health Dent 2014 Jan;3:175-180. |
Teaching
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| Date | Description | Institution | # Students |
| - Present | Post-Doctoral Student Supervision | ||
| - Present | Post-Doctoral Student Supervision | ||
| 1/2018 - Present | Dent 208 - Pulp Biology | ||
| Course Director - This sophomore course builds on the students?h knowledge of the dental pulp/dentin complex in terms of its anatomy and physiology. The course reviews the pathogenesis and diagnosis of pulpal and periapical diseases. In addition, treatment options for teeth with vital and non-vital pulps are discussed. After assuming the responsibility of course directorship, I modified the course to included videos and inter-active learning. 1.5 credit hours | |||
| 1/2017 - Present | Individual Instruction | UNC | |
| 1/2017 - 1/2021 | Membership on Supervising Committee | ||
| 1/2014 - Present | OBIO 723 - Introduction to Pain Neurobiology | ||
| The objectives of this course are: to provide advanced level understanding of the underlying biological processes that contribute to the transmission and modulation of pain; to describe pharmacologic management of acute and chronic pain and; to highlight research approaches in the pain field that will facilitate better patient outcomes by way of individualized prognostic indicators and treatments. 1 credit hour. | |||
| 1/2014 - Present | OBIO 732 - Introduction to Pain Neurobiology | ||
| The objectives of this course are: to provide advanced level understanding of the underlying biological processes that contribute to the transmission and modulation of pain; to describe pharmacologic management of acute and chronic pain and; to highlight research approaches in the pain field that will facilitate better patient outcomes by way of individualized prognostic indicators and treatments. 1 credit hour | |||
| 1/2008 - Present | Endo 750 - Endodontic Graduate Clinic | ||
| Graduate Clinical Endodontics involves the instruction of Endodontic residents in advance clinical endodontic training. Areas of training include diagnosis, treatment planning and the use of traditional and contemporary procedures and armamentarium. 3 credit hours | |||
| 1/2008 - Present | Dent 330 - Clinical Endodontics | ||
| Course Director - These courses represents the clinical implementation of knowledge and skills obtained in the preclinical courses and allows students to develop their clinical skills in endodontic procedures. Dent 330 is for Junior DDS students and Dent 430 is for Seniors. This clinical opportunity is structured so that students can begin to master the primary procedures in endodontics, including diagnosis, management of endodontic emergencies, primary root canal treatment and determination of treatment outcomes. 1 credit hour. | |||
| 1/2008 - Present | Dent 430 - Clinical Endodontics | ||
| Course Director - These courses represents the clinical implementation of knowledge and skills obtained in the preclinical courses and allows students to develop their clinical skills in endodontic procedures. Dent 330 is for Junior DDS students and Dent 430 is for Seniors. This clinical opportunity is structured so that students can begin to master the primary procedures in endodontics, including diagnosis, management of endodontic emergencies, primary root canal treatment and determination of treatment outcomes. 1 credit hour. | |||
| 1/2008 - Present | Endo 740 - Endodontic Graduate Clinic | ||
| Graduate Clinical Endodontics involves the instruction of Endodontic residents in advance clinical endodontic training. Areas of training include diagnosis, treatment planning and the use of traditional and contemporary procedures and armamentarium. 3 credit hours | |||
| 1/2008 - Present | Endo 730 - Endodontic Graduate Clinic | ||
| Graduate Clinical Endodontics involves the instruction of Endodontic residents in advance clinical endodontic training. Areas of training include diagnosis, treatment planning and the use of traditional and contemporary procedures and armamentarium. 3 credit hours. | |||
| 1/2008 - Present | Endo 720 - Endodontic Graduate Clinic | ||
| Graduate Clinical Endodontics involves the instruction of Endodontic residents in advance clinical endodontic training. Areas of training include diagnosis, treatment planning and the use of traditional and contemporary procedures and armamentarium. 3 credit hours | |||
| 1/2008 - Present | Endo 710 - Endodontic Graduate Clinic | ||
| Graduate Clinical Endodontics involves the instruction of Endodontic residents in advance clinical endodontic training. Areas of training include diagnosis, treatment planning and the use of traditional and contemporary procedures and armamentarium. 3 credit hours. | |||
| 1/2008 - Present | Endo 812 - Literature Review | ||
| This is a 2 credit hour course where faculty facilitate discussion on the classic endodontic literature | |||
| 1/2008 - Present | Dent 220 - Preclinical Endodontics | ||
| The Preclinical Endodontics Course is designed to prepare the student for the clinical experiences that begin in the Fall of the Junior year. A series of lectures relating to the techniques used in root canal treatment are a part of the preclinical course. In separate laboratory sessions, students apply the principles and techniques learned in the lecture portion of the course on simulated teeth. 3 credit hours | |||
| 1/2001 - Present | Fundamentals of Endodontics | ||
| This course, given to incoming residents, provides a foundation for endodontic diagnosis, treatment planning procedures, prognosis, practice issues and research. 3 credit hours. | |||