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  • Diogenes, Anibal

Anibal Diogenes, D.D.S., M.S., Ph.D.

Dental School
Endodontics
210-567-3381
diogenes@uthscsa.edu

Anibal Diogenes, DDS, MS, PhD

Dr. Anibal Diogenes received his D.D.S. from the Federal University of Pernambuco in Brazil, his M.S. in Molecular Biology from the University of Nebraska, and his Ph.D. in Pharmacology and Certificate in Endodontics from the University of Texas Health Science Center at San Antonio. Dr. Diogenes is a professor and the vice-chair of the Department of Endodontics at the University of Texas Health Science Center at San Antonio. His areas of research include pain, neuroscience and regenerative endodontics. He is also an Associate Editor for the Journal of Endodontics and a director of the American Board of Endodontics. Dr. Diogenes maintains a private practice limited to Endodontics in addition to his teaching and research activities.

  • Education
  • Appointments
  • Expertise
  • Publications
  • Teaching
  • Grants

Education

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Year Degree Discipline Institution
2009 Residency Endodontics University of Texas Health Science Center at San Antonio San Antonio , TX
2009 Certificate Endodontics University of Texas Health Science Center San Antonio San Antonio , TX
2009 Postdoctoral Fellowship Pharmacology University of Texas Health Science Center, Dept of Endodontics San Antonio , TX
2006 PhD Pharmacology University Texas Health Science Center San Antonio San Antonio , TX
2002 MS Molecular Biology University of Nebraska Kearney , NE
1998 DDS Dentistry Federal Univ. of Pernambuco Recife, Pernambuco , Brazil

Appointments

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9/2019 - Present Professor and Vice Chair UT Health San Antonio, Endodontics, San Antonio, TX
11/2015 - Present Adjunct Professor Uniformed Services University of the Health Sciences, Endodontics, San Antonio, TX
9/2015 - Present Associate Professor with Tenure University of Texas Health Science Center at San Antonio, Endodontics, San Antonio, TX
2/2015 - Present Associate Professor Cross Appointment University of Texas Health Science Center at San Antonio, Cellular & Structural Biology, San Antonio, TX
1/2015 - Present Associate Professor Post-Doctoral Director University of Texas Health Science Center at San Antonio, San Antonio, TX
1/2009 - Present Private Practice Limited to Endodontics University of Texas Health Science Center at San Antonio, San Antonio, TX
1/2009 - Present Associate Editor Journal of Endodontics

Expertise

Areas of Research Interests - Research interest include the peripheral modulation of nociceptors by inflammatory mediators and microbial specific antigens, and the application of bioengineering and stem cells in Endodontics.

Publications

Abstract

Ruparel N. Bacterial Byproducts/Biofilm Affect Differentiation of Stem Cells of Apical Papilla; 2016 Jan. (AADR Abstract 0750).

Journal Article

De Berdt P, Bottemanne P, Bianco J, Alhouayek M, Diogenes A, Lloyd A, et al. Author Correction: Stem cells from human apical papilla decrease neuroinflammation and stimulate oligodendrocyte progenitor differentiation via activinA secretion Cell Mol Life Sci 2018 Jan;.
Miller AA, Takimoto K, Wealleans J, Diogenes A. Effect of 3 Bioceramic Materials on Stem Cells of the Apical Papilla Proliferation and Differentiation Using a Dentin Disk Model J Endod 2018 2018 Jan;44(4):599-603.
De Berdt P, Bottemanne P, Bianco J, Alhouayek M, Diogenes A, Lloyd A. Stem cells from human apical papilla decrease neuroinflammation and stimulate oligodendrocyte progenitor differentiation via activin-A secretion Cell Mol Life Sci. 2018 2018 Jan;.
Estrela C, Couto GS, Bueno MR, Bueno KG, Estrela LRA, Porto OCL, Diogenes A. Apical foramen position in relation to proximal root surfaces of human permanent teeth determined by using a new cone-beam computed tomographic software Journal of Endodontics 2018 Jan;.
Arruda MEF, Neves MAS, Diogenes A, Mdala I, Guilherma BPS, Siqueira JR Jr., Rocas IN. Infection control in teeth with apical periodontitis using a triple antibiotic solution or calcium hydroxide with chlorhexidine: A randomized clinical trial Journal of Endodontics 2018 Jan;44(10):1474-1479.
Vishwanat L, Duong R, Takimoto K, Phillips L, Espitia CO, Diogenes A, Ruparel SB, Kolodrubetz D, Ruparel NB. Effect of Bacterial Biofilm on the Osteogenic Differentiation of Stem Cells of Apical Papilla Journal of Endodontics 2017 Jun;43(6):916-922.
Song JS, Takimoto K, Jeon M, Vadakekalam J, Ruparel NB,Diogenes A. Decellularized Human Dental Pulp as a Scaffold for Regenerative Endodontics Journal of Dental Research 2017 Jan;96(6):640-646.
Chrepa V, Austah O,Diogenes A. Evaluation of a Commercially Available Hyaluronic Acid Hydrogel (Restylane) as Injectable Scaffold for Dental Pulp Regeneration: An In Vitro Evaluation Journal of Endodontics 2017 Jan;43(2):257-262.
Diogenes A, Hargreaves KM. Microbial Modulation of Stem Cells and Future Directions in Regenerative Endodontics Journal of Endodontics 2017 Jan;43(9S):S95-S101.
Viswanath A, Vanacker J, Germain L, Leprince JG, Diogenes A, Shakesheff KM, et al. Extracellular matrix-derived hydrogels for dental stem cell delivery Journal of Biomed Mater Res A 2017 Jan;105(1):319-328.
Palma PJ, Ramos JC, Martins JB, Diogenes A, Figueiredo MH, Ferreira P, et al. Histologic Evaluation of Regenerative Endodontic Procedures with the Use of Chitosan Scaffolds in Immature Dog Teeth with Apical Periodontitis Journal of Endodontics 2017 Jan;43(8):1279-1287.
Eskander, M.A., Takimoto, K., Diogenes A. Evaluation of mesenchymal stem cell modulation of trigeminal neuronal responses to cold Neuroscience 2017 Jan;360:61-67.
Chrepa V, Pitcher B, Henry MA, Diogenes A. Survival of the Apical Papilla and Its Resident Stem Cells in a Case of Advanced Pulpal Necrosis and Apical Periodontitis Journal of Endodontics 2017 Jan;43(4):561-567.
Fayazi S, Takimoto K,Diogenes A. Comparative Evaluation of Chemotactic Factor Effect on Migration and Differentiation of Stem Cells of the Apical Papilla Journal of Endodontics 2017 Jan;43(8):1288-1293.
Estefan BS, El Batouty KM, Nagy MM,Diogenes A. Influence of Age and Apical Diameter on the Success of Endodontic Regeneration Procedures Journal of endodontics 2016 Jan;42(11):1620-1625.
Yuan C, Wang P, Zhu S, Zou T, Wang S, Xu J, Heng BC, Diogenes A, Zhang C. EphrinB2 Stabilizes Vascular like Structures Generated by Endothelial Cells and Stem Cells from Apical Papilla Journal of Endodontics 2016 Jan;42(9):1362-1370.
Austah O, Ruparel NB, Henry MA, Fajardo R, Schmitz JE, Diogenes A. Capsaicin-sensitive Innervation Modulates the Development of Apical Periodontitis Journal of Endodontics 2016 Jan;42(10):1496-1502.
Diogenes A, Ruparel N, Shiloah Y, Hargreaves KM. Regenerative endodontics: A way forward J Am Dent Assc 2016 Jan;147(5):372-380.
Smith AJ, Duncan HF, Diogenes A, Simon S, Cooper PR. Exploiting the Bioactive Properties of the Dentin-Pulp Complex in Regenerative Endodontics Journal of Endodontics 2016 Jan;42(1):47-56.
Kishen A, Peters OA, Zehnder M, Diogenes A, Nair MK. Advances in endodontics: Potential applications in clinical practice J Conserv Dent 2016 Jan;19(3):199-206.
Shrestha S, Diogenes A, Kishen A. Temporal-controlled Dexamethasone Releasing Chitosan Nanoparticle System Enhances Odontogenic Differentiation of Stem Cells from Apical Papilla Journal of Endodontics 2015 Jan;41(8):1253-1258.
Germain L, De Berdt P, Vanacker J, Leprince J, Diogenes A, Jacobs D, et al. Fibrin hydrogels to deliver dental stem cells of the apical papilla for regenerative medicine Regen Med 2015 Jan;10(2):153-167.
Middleton G, Diogenes A. Preemptive Nonsteroidal Anti-inflammatory Drugs Increases the Success Rate of Inferior Alveolar Nerve Blocks in Mandibular Posterior Teeth with Symptomatic Irreversible Pulpitis Texas Dental 2015 Jan;132(6):358-358.
De Berdt P, Vanacker J, Ucakar B, Elens L, Diogenes A, Leprince JG, et al. Dental Apical Papilla as Therapy for Spinal Cord Injury J Dent Res 2015 Jan;94(11):1575-1581.
Chrepa V, Henry MA, Daniel BJ, Diogenes A. Delivery of apical mesenchymal stem cells into root canals of mature teeth Journal of Dental Research 2015 Jan;94(12):1653-1659.

Review Article

Diogenes A, Ruparel NB. Regenerative Endodontic Procedures: Clinical Outcomes Dental Clinic North America 2017 Jan;61(1):111-125.

Teaching

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Date Description Institution # Students
1/2015 - Present Ph.D. Dissertations Directed UTHSCSA  
 
7/2014 - Present Clinical Endodontics I The University of Texas Health Science Center 4 students
Course Director - 40 hours. 4 students enrolled. In Graduate Endodontics Clinic, students are expected to be able to diagnose oral disease of endodontic origin and provide satisfactory non-surgical and surgical treatment of endodontic disease.
7/2014 - Present Clinical Endodontics III The University of Texas Health Science Center  
Course Director - 72 hours. 1 student enrolled. In Graduate Endodontics Clinic, students are expected to be able to diagnose oral disease of endodontic origin and provide satisfactory non-surgical and surgical treatment of endodontic disease.
7/2014 - Present Case Presentations III The University of Texas Health Science Center  
Course Director - 16 hours. 1 student enrolled. The goal of this course is to help the student develop a biologic understanding and scientific basis for the diagnosis and treatment of endodontic cases. This will be accomplished through the presentation of Powerpoint slide shows of these cases, thus a secondary goal is help the student in their organization and presentations skills.
7/2014 - Present Case Presentations III The University of Texas Health Science Center  
Course Director - 32 hours. 1 student enrolled. The goal of this course is to help the student develop a biologic understanding and scientific basis for the diagnosis and treatment of endodontic cases. This will be accomplished through the presentation of Powerpoint slide shows of these cases, thus a secondary goal is help the student in their organization and presentations skills.
7/2014 - Present Clinical Sem II The University of Texas Health Science Center  
Course Director - 72 hours. 4 students enrolled. This course is intended to introduce the endodontic resident to the existing body of literature of our specialty. The articles are selected according to their impact on clinical and biological considerations pertinent to the understanding of the endodontic practice. Subjects are broad in scope and cover the majority of topics and treatment alternatives of classic, relevant and contemporary literature. These manuscripts are discussed and evaluated, placing emphasis on their strength to already existing endodontic comprehension.
7/2014 - Present Case Presentations II The University of Texas Health Science Center  
Course Director - 64 hours. 4 students enrolled. The goal of this course is to help the student develop a biologic understanding and scientific basis for the diagnosis and treatment of endodontic cases. This will be accomplished through the presentation of Powerpoint slide shows of these cases, thus a secondary goal is help the student in their organization and presentations skills.
7/2014 - Present Supervised Teaching The University of Texas Health Science Center  
Course Director - 16 hours. 4 students enrolled. In this class, residents are require to develop teaching skills to be able to demonstrate non-surgical endodontic techniques to sophomore Predoctoral students in a laboratory setting.
7/2014 - Present Clinical Endo II The University of Texas Health Science Center  
Course Director - 8 hours. 8 students enrolled. In Graduate Endodontics Clinic residents are expected to be able to diagnose oral disease of endodontic origin and provide satisfactory non-surgical and surgical treatment of endodontic disease. In this course, students are required to make use of advanced imaging (CBCT), diagnostic tests and planning tools such as intraoral scans and 3D planning softwares to reach an accurate diagnosis and treatment plan.
7/2014 - Present Case Presentations II The University of Texas Health Science Center  
Course Director - 64 hours. 4 students enrolled. The goal of this course is to help the student develop a biologic understanding and scientific basis for the diagnosis and treatment of endodontic cases. This will be accomplished through the presentation of Powerpoint slide shows of these cases, thus a secondary goal is help the student in their organization and presentations skills.
7/2014 - Present Case Presentations II The University of Texas Health Science Center  
Course Director - 16 hours. 4 students enrolled. The goal of this course is to help the student develop a biologic understanding and scientific basis for the diagnosis and treatment of endodontic cases. This is be accomplished through the presentation of PowerPoint slide shows of actual clinical cases, thus a secondary goal is help the student in their organization and presentations skills.
7/2014 - Present Lit Review II The University of Texas Health Science Center  
Course Director - 64 hours. 4 students enrolled. This course is intended to introduce the endodontic resident application manuscripts related to our specialty. The articles are selected according to their impact on clinical and biological considerations pertinent to the understanding of the endodontic practice. Subjects will be broad in scope and will cover the majority of topics and treatment alternatives of classic, relevant and contemporary literature. These manuscripts will be discussed and evaluated, placing emphasis on their strength to already existing endodontic comprehension.
7/2014 - Present Literature Review II The University of Texas Health Science Center  
Course Director - 16 hours. 4 students enrolled. This course is intended to introduce the endodontic resident to the existing body of literature of our specialty. The articles are selected according to their impact on clinical and biological considerations pertinent to the understanding of the endodontic practice. Subjects are broad in scope and cover the majority of topics and treatment alternatives of classic, relevant and contemporary literature. These manuscripts are be discussed and evaluated, placing emphasis on their strength to already existing endodontic comprehension.
7/2014 - Present Literature Review I The University of Texas Health Science Center  
Course Director - 64 hours. 6 students enrolled. This course is intended to introduce the endodontic resident application manuscripts related to our specialty. The articles are selected according to their impact on clinical and biological considerations pertinent to the understanding of the endodontic practice. Subjects will be broad in scope and will cover the majority of topics and treatment alternatives of classic, relevant and contemporary literature. These manuscripts will be discussed and evaluated, placing emphasis on their strength to already existing endodontic comprehension.
7/2014 - Present Literature Review I The University of Texas Health Science Center  
Course Director - 64 hours. 8 students enrolled. This course is intended to introduce the endodontic resident application manuscripts related to our specialty. The articles are selected according to their impact on clinical and biological considerations pertinent to the understanding of the endodontic practice. Subjects will be broad in scope and will cover the majority of topics and treatment alternatives of classic, relevant and contemporary literature. These manuscripts will be discussed and evaluated, placing emphasis on their strength to already existing endodontic comprehension.
7/2014 - Present Literature Review I The University of Texas Health Science Center  
Course Director - 16 hours. 8 students enrolled. This course is intended to introduce the endodontic resident application manuscripts related to our specialty. The articles are selected according to their impact on clinical and biological considerations pertinent to the understanding of the endodontic practice. Subjects will be broad in scope and will cover the majority of topics and treatment alternatives of classic, relevant and contemporary literature. These manuscripts will be discussed and evaluated, placing emphasis on their strength to already existing endodontic comprehension.
7/2014 - Present Clinical Endodontics II The University of Texas Health Science Center  
Course Director - 8 hours. 8 students enrolled. In Graduate Endodontics Clinic residents are expected to be able to diagnose oral disease of endodontic origin and provide satisfactory non-surgical and surgical treatment of endodontic disease. In this course, students are required to make use of advanced imaging (CBCT), diagnostic tests and planning tools such as intraoral scans and 3D planning software's to reach an accurate diagnosis and treatment plan.
7/2014 - Present Clinical Endo II The University of Texas Health Science Center  
Course Director - 48 hours. 8 students enrolled. In Graduate Endodontics Clinic residents are expected to be able to diagnose oral disease of endodontic origin and provide satisfactory non-surgical and surgical treatment of endodontic disease. In this course, students are required to make use of advanced imaging (CBCT), diagnostic tests and planning tools such as intraoral scans and 3D planning software?es to reach an accurate diagnosis and treatment plan.
7/2014 - Present Case Presentations I The University of Texas Health Science Center  
Course Director - 64 hours. 8 students enrolled. The goal of this course is to help the student develop a biologic understanding and scientific basis for the diagnosis and treatment of endodontic cases. This will be accomplished through the presentation of Powerpoint slide shows of actual clinical cases, thus a secondary goal is help the student in their organization and presentations skills.
7/2014 - Present Supervised Teaching The University of Texas Health Science Center  
Course Director - 16 hours. 6 students enrolled. In this class, residents are require to develop teaching skills to be able to demonstrate non-surgical endodontic techniques to sophomore Predoctoral students in a laboratory setting.
7/2014 - Present ENDO Surgical Anatomy The University of Texas Health Science Center  
Course Director - 24 hours. 6 students enrolled. This course consists of a series of four, four-hour seminar sessions devoted to an in-depth discussion of endodontic surgical anatomy, surgical indications and techniques, and wound healing. This is followed by twenty hours of laboratory during which human head and neck prosected specimens are covered to demonstrate pertinent anatomic structures and the students practice actual surgical procedures on anterior, premolar, and molar teeth in cadaver specimens.
7/2014 - Present Clinical Seminar I The University of Texas Health Science Center  
Course Director - 32 hours. 8 students enrolled. This course is intended to bring, to the endodontic resident, appropriate and important topics related to our specialty. The seminars are selected according to their impact on clinical and biological considerations pertinent to clinical practice. Subjects will be broad in scope and will cover the majority of issues and treatment alternatives in contemporary endodontics. Discussions will be implemented and evaluated, placing emphasis on the resident?s understanding of subjects.
7/2014 - Present Case Presentations I The University of Texas Health Science Center  
Course Director - 64 hours. 8 students enrolled. The goal of this course is to help the student develop a biologic understanding and scientific basis for the diagnosis and treatment of endodontic cases. This will be accomplished through the presentation of Powerpoint slide shows of actual clinical cases, thus a secondary goal is help the student in their organization and presentations skills.
7/2014 - Present Case Presentations I The University of Texas Health Science Center  
Course Director - 8 hours. 8 students enrolled. The goal of this course is to help the student develop a biologic understanding and scientific basis for the diagnosis and treatment of endodontic cases. This will be accomplished through the presentation of Powerpoint slide shows of actual clinical cases; thus, a secondary goal is help the student in their organization and presentations skills.
7/2014 - Present Clinical Seminar I The University of Texas Health Science Center  
Course Director - 32 hours. 6 students enrolled. This course is intended to bring, to the endodontic resident, appropriate and important topics related to our specialty. The seminars are selected according to their impact on clinical and biological considerations pertinent to clinical practice. Subjects will be broad in scope and will cover the majority of issues and treatment alternatives in contemporary endodontics. Discussions will be implemented and evaluated, placing emphasis on the resident?s understanding of subjects.
4/2014 - Present ENDO5011 Clinical Endodontics I    
Course Director - 48 hours. 6 students enrolled. In Graduate Endodontics Clinic, students are expected to be able to diagnose oral disease of endodontic origin and provide satisfactory non-surgical and surgical treatment of endodontic disease.
1/2014 - Present Post-Doctoral Student Supervision    
 
1/2009 - Present Current Literature Review The University of Texas Health Science Center  
Co-Course Director - 8 hours. 9 students enrolled. The goal of this course is to help residents form the scientific foundation necessary for understanding the biology of the various processes related to Endodontics, and to formulate the critical analytical skills necessary to evaluate current scientific literature in order to guide in the evidence-based clinical decision-making. Each resident is assigned specific recently published articles for review at the discretion of the course director. Written abstracts of these articles are prepared and orally presented by the resident to the class. It is highly encouraged that a section entitled: ?Discussion? is present in the abstract in which the resident succinctly evaluates the presented study in the light of the present scientific literature.
1/2009 - Present Current Literature Review The University of Texas Health Science Center  
Co-Course Director - 16 hours. 9 students enrolled. The goal of this course is to help residents form the scientific foundation necessary for understanding the biology of the various processes related to Endodontics, and to formulate the critical analytical skills necessary to evaluate current scientific literature in order to guide in the evidence-based clinical decision-making. Each resident is assigned specific recently published articles for review at the discretion of the course director. Written abstracts of these articles are prepared and orally presented by the resident to the class. It is highly encouraged that a section entitled: ?Discussion? is present in the abstract in which the resident succinctly evaluates the presented study in the light of the present scientific literature.
1/2009 - Present ENDO6077 Current Literature Review    
Co-Course Director - 16 hours. 8 students enrolled. This course is intended to introduce the endodontic resident application manuscripts related to our specialty. The articles are selected according to their impact on clinical and biological considerations pertinent to the understanding of the endodontic practice. Subjects will be broad in scope and will cover the majority of topics and treatment alternatives of classic, relevant and contemporary literature. These manuscripts will be discussed and evaluated, placing emphasis on their strength to already existing endodontic comprehension.
1/2009 - Present HHD5004 Histology   100 students
4 hours. 100 students enrolled. In this class, I lecture on stem cell biology in dentistry (2 hrs) and embryology of dentinogenesis (2hrs).
1/2009 - Present Pharmacology The University of Texas Health Science Center 6 students
3 hours. 6 students enrolled. In this course offered to graduate students in pharmacology, I lecture on the pharmacology of local anesthetics and therapeutics.
1/2009 - Present PHAR5041 Pharmacology    
2 hours. 100 students enrolled. In this freshman course, I lecture on local anesthetics (2hrs).

Grants

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Private

Funding Agency AAEF
Title Regeneration of pulp-dentin development in immature permanent teeth with necrosis
Status Active
Period 1/2010 - Present
Role Co-Investigator
Grant Detail This is a a 5-year grant to conduct a multi-center clinical trial comparing a regenerative endodontic treatment to MTA Apexification procedures .

 

Funding Agency NIDCR
Title Trigeminal Afferent Regulation of Apical Periodontitis
Status Active
Period 7/2018 - Present
Role Principal Investigator
Grant Detail Grant Detail: This is a a 5-year grant to evaluate how different trigeminal afferent subtypes modulate the development and maintenance of apical periodontitis

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