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Brij Singh, Ph.D.
Dental School
Periodontics
210-567-3798
singhbb@uthscsa.edu
Education
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| Year | Degree | Discipline | Institution |
| 2002 | Postdoctoral Fellowship | Gene Therapy & Therapeutics Branch | National Institutes of Health Bethesda , MD |
| 1999 | Postdoctoral Fellowship | Pharmacology & Therapeutics | Medical College of Wisconsin Milwaukee , WI |
| 1998 | Postdoctoral Fellowship | Molecular Biochemistry Section | University of Bonn Bonn , Germany |
| 1997 | PhD | Biochemistry (Awarded DAAD fellowship (sandwich model) to carry out PhD research in Germany.) | Bhopal University India & the University of Bonn Germany Bonn , India & Germany |
| 1995 | Postdoctoral Training | Human Resource Management | Indira Gandhi Open National University India |
| 1993 | MS | Biotechnology | Aligarh University (AMU) Aligarh , India |
| 1991 | BS | Biology with Minor in Chemistry | Aligarh University (AMU) Aligarh , India |
Appointments
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| 11/2017 - Present | Associate Dean for Research | UT Health San Antonio, San Antonio, TX |
| 11/2017 - Present | Professor with Tenure | UT Health San Antonio, Periodontics, San Antonio, TX |
Expertise
| Cell Signaling - Calcium signaling, salivary gland physiology, Sjogrens syndrome, ER stress, Immunology, Cell Death and proliferation, apoptosis, autophagy. |
Publications
Journal Article |
| Bhattacharya A, Kumar J. Qureshi H, Sun Y, Hermanson K, Perley D, Scheidegger A, Singh BB, Dhasarathy A (2018). The calcium channel ORAI3 mediates SNAIL expression during TGF-B induced EMT Oncotarget 2018 Jun;9(50):29468-29483. |
| Sun Y, Schaar A, Sukumaran P, Dhasarathy A, Singh BB (2018). Epithelial-to-Mesenchymal Transition in Prostate Cancer Cells is mediated via TRPM7 expression Molecular Carcinogenesis 2018 Jun;57(6):752-761. |
| Sukumaran P, Sun Y, Antonson N, Singh BB (2018). Dopaminergic neurotoxins induce cell death by attenuating NFkB-mediated regulation of TRPC1 expression and autophagy FASEB Journal 2018 Mar;32(3):1640-1652. |
| Bollimuntha S, Pani B, Singh BB. Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function Advances in Experimental Medicine and Biology 2017 Jan;993:535-556. |
| Krout D, Schaar A, Sun Y, Sukumaran P, Roemmich JN, Claycombe-Larson KJ, Singh BB. Loss of TRPC1 is required for exercise-induced protection against high-fat diet-induced obesity and type II diabetes Journal of Biological Chemistry 2017 Jan;292(50):20799-20807. |
| Sun Y, Zhang H, Selvaraj S, Sukumaran P, Lei S, Birnbaumer L, Singh BB. Inhibition of Ca v 1.3 channels by STIM1 in dopaminergic neurons is regulated by TRPC1 Journal of Neuroscience 2017 Jan;37(12):3364-3377. |
| Sukumaran P, Sun Y, Schaar A, Selvaraj S, and Singh BB. The role of TRPC channels in Parkinson`s disease. In TRPC Channels and Brain Diseases (Eds Jun Feng Wang)Springer Nature Advances in Experimental Medicine and Biology 2017 Jan;976:85-94. |
| Sun Y, Sukumaran P, Selvaraj S, Schaar A, Cilz N, Lei S, Singh BB. TRPM2 inhibition protects neurotoxin MPP+- induced oxidative stress-mediated cell degeneration. [Epub ahead of print Molecular Neurobiology Molecular Neurobiology 2016 Dec;. |
| Schaar A, Sun Y, Sukumaran P, Dhasarathy A, and Singh BB. TRPC1 and STIM1 are critical for TGFβ induced EMT migration through regulation of calpains Oncotarget 2016 Oct;7(49):80554-80567. |
| Sukumaran P, Schaar A, Sun Y, Singh BB. Functional role of TRP channels in modulating ER stress and Autophagy Cell Calcium 2016 Aug;60(2):123-132. |
| Madeo M, Sun Y, Chandrasekar I, Yarrow A, Cordeiro D, McCormick EM, Murarescu CC, Nolan PM, Acevedo-Arozena A, Singh BB, Kruer MC. Loss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy American Journal of Human Genetics (Cell Press) 2016 Jun;98(6):1249-1255. |
| Chauhan A, Quenum F, Abbas A, Bradley DA, Nechaev S, Singh BB, Sharma J, Mishra BB. Epigenetic modulation of microglial inflammatory gene loci in helminth-induced immune suppression. pii: 1759091415592126 ASN Neuro 2015 Jul;7(4). |
| Sukumaran P, Sun Y, Vyas M, Singh BB. TRPC1-mediated Ca2+ entry is essential for the regulation of hypoxia and nutrient depletion-dependent autophagy in salivary gland cells Cell Death and Disease 2015 Mar;6. |
Teaching
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| Date | Description | Institution | # Students |
| - Present | Membership on Supervising Committee | University of North Dakota | |
| - Present | BIMD 503 | ||
| Delivered 1 lecture and worked with BIMD 503 module graduate students for a week (7 contact hours). Also was involved in evaluating and public speaking. | |||
Grants
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Federal |
|
| Funding Agency | NIH, NIDCR |
| Title | Epigenetic regulation in Sjogerns syndrome |
| Status | Active |
| Period | 8/2017 - 7/2022 |
| Role | Principal Investigator |
| Grant Detail | The long-term goal of this project is to elucidate the role of epigenetic regulations in the onset of Sjogren`s Syndrome. |
| Funding Agency | NIH, NIGMS |
| Title | Center for Excellence In-Host Pathogen Interactions (relinquished as moved to UT Health San Antonio) |
| Status | Active |
| Period | 5/2016 - 5/2021 |
| Role | Principal Investigator |
| Grant Detail | The long-term goal of this program project grant (COBRE) is to establish a center for host pathogen interaction. |
| Funding Agency | NIH, NIDCR |
| Title | TRPC1 calcium and exocrine function |
| Status | Active |
| Period | 7/2005 - 9/2020 |
| Role | Principal Investigator |
| Grant Detail | The long term-goal of this project is to identify and elucidate the mechanism of the role of TRPC1 function in salivary glands secretion and regulation. |
| Funding Agency | NIH, NIAID |
| Title | Lung innate immunity against bacterial infection |
| Status | Active |
| Period | 9/2012 - 8/2018 |
| Role | Co-Investigator |
| Grant Detail | The goal of this project is to determine the role of ATG-7-mediated autophagy in protection against gram-negative bacteria in bacterial clearance by alveolar macrophages. |
| Funding Agency | NIH, NIHES |
| Title | Environmental toxins and stem cell epigenetic remodeling |
| Status | Complete |
| Period | 9/2012 - 8/2018 |
| Role | Co-Investigator |
| Grant Detail | The long-term goal of this project is to identify the relationship between environmental toxins and epigenetic regulation in Parkinson`s disease. |
| Funding Agency | NIH, NIDCR |
| Title | Galectins as novel alarmins in salivary gland inflammation |
| Status | Complete |
| Period | 7/2015 - 6/2018 |
| Role | Principal Investigator |
| Grant Detail | The long-term goal of this project is to identify the role of alarmins in regulating inflammation. |
| Funding Agency | Infrastructure Improvement Program (IIP) - Equipment Grants ND-EPSCoR |
| Title | Calcium Imaging Facility at University of North Dakota |
| Status | Complete |
| Period | - Present |
| Role | Principal Investigator |
| Grant Detail | |