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Brij Singh, Ph.D.
Dental School
Periodontics
210-567-3798
singhbb@uthscsa.edu
Education
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| Year | Degree | Discipline | Institution |
| 2002 | Postdoctoral Fellowship | Gene Therapy & Therapeutics Branch | National Institutes of Health Bethesda , MD |
| 1999 | Postdoctoral Fellowship | Pharmacology & Therapeutics | Medical College of Wisconsin Milwaukee , WI |
| 1998 | Postdoctoral Fellowship | Molecular Biochemistry Section | University of Bonn Bonn , Germany |
| 1997 | PhD | Biochemistry (Awarded DAAD fellowship (sandwich model) to carry out PhD research in Germany.) | Bhopal University India & the University of Bonn Germany Bonn , India & Germany |
| 1995 | Postdoctoral Training | Human Resource Management | Indira Gandhi Open National University India |
| 1993 | MS | Biotechnology | Aligarh University (AMU) Aligarh , India |
| 1991 | BS | Biology with Minor in Chemistry | Aligarh University (AMU) Aligarh , India |
Appointments
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| 11/2017 - Present | Professor with Tenure | UT Health San Antonio, Periodontics, San Antonio, TX |
| 11/2017 - Present | Associate Dean for Research | UT Health San Antonio, San Antonio, TX |
Expertise
|
Cell Signaling - Calcium signaling, salivary gland physiology, Sjogrens syndrome, ER stress, Immunology, Cell Death and proliferation, apoptosis, autophagy. |
Publications
Journal Article |
| Bhattacharya A, Kumar J. Qureshi H, Sun Y, Hermanson K, Perley D, Scheidegger A, Singh BB, Dhasarathy A (2018). The calcium channel ORAI3 mediates SNAIL expression during TGF-B induced EMT Oncotarget 2018 Jun;9(50):29468-29483. |
| Sun Y, Schaar A, Sukumaran P, Dhasarathy A, Singh BB (2018). Epithelial-to-Mesenchymal Transition in Prostate Cancer Cells is mediated via TRPM7 expression Molecular Carcinogenesis 2018 Jun;57(6):752-761. |
| Sukumaran P, Sun Y, Antonson N, Singh BB (2018). Dopaminergic neurotoxins induce cell death by attenuating NFkB-mediated regulation of TRPC1 expression and autophagy FASEB Journal 2018 Mar;32(3):1640-1652. |
| Sun Y, Zhang H, Selvaraj S, Sukumaran P, Lei S, Birnbaumer L, Singh BB. Inhibition of Ca v 1.3 channels by STIM1 in dopaminergic neurons is regulated by TRPC1 Journal of Neuroscience 2017 Jan;37(12):3364-3377. |
| Bollimuntha S, Pani B, Singh BB. Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function Advances in Experimental Medicine and Biology 2017 Jan;993:535-556. |
| Krout D, Schaar A, Sun Y, Sukumaran P, Roemmich JN, Claycombe-Larson KJ, Singh BB. Loss of TRPC1 is required for exercise-induced protection against high-fat diet-induced obesity and type II diabetes Journal of Biological Chemistry 2017 Jan;292(50):20799-20807. |
| Sukumaran P, Sun Y, Schaar A, Selvaraj S, and Singh BB. The role of TRPC channels in Parkinson`s disease. In TRPC Channels and Brain Diseases (Eds Jun Feng Wang)Springer Nature Advances in Experimental Medicine and Biology 2017 Jan;976:85-94. |
| Sun Y, Sukumaran P, Selvaraj S, Schaar A, Cilz N, Lei S, Singh BB. TRPM2 inhibition protects neurotoxin MPP+- induced oxidative stress-mediated cell degeneration. [Epub ahead of print Molecular Neurobiology Molecular Neurobiology 2016 Dec;. |
| Schaar A, Sun Y, Sukumaran P, Dhasarathy A, and Singh BB. TRPC1 and STIM1 are critical for TGFβ induced EMT migration through regulation of calpains Oncotarget 2016 Oct;7(49):80554-80567. |
| Sukumaran P, Schaar A, Sun Y, Singh BB. Functional role of TRP channels in modulating ER stress and Autophagy Cell Calcium 2016 Aug;60(2):123-132. |
| Madeo M, Sun Y, Chandrasekar I, Yarrow A, Cordeiro D, McCormick EM, Murarescu CC, Nolan PM, Acevedo-Arozena A, Singh BB, Kruer MC. Loss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy American Journal of Human Genetics (Cell Press) 2016 Jun;98(6):1249-1255. |
| Chauhan A, Quenum F, Abbas A, Bradley DA, Nechaev S, Singh BB, Sharma J, Mishra BB. Epigenetic modulation of microglial inflammatory gene loci in helminth-induced immune suppression. pii: 1759091415592126 ASN Neuro 2015 Jul;7(4). |
| Sukumaran P, Sun Y, Vyas M, Singh BB. TRPC1-mediated Ca2+ entry is essential for the regulation of hypoxia and nutrient depletion-dependent autophagy in salivary gland cells Cell Death and Disease 2015 Mar;6. |
| Sun Y, Sukumaran P, Schaar A, Singh BB. TRPM7 and its role in neurodegenerative diseases Channels 2015 Jan;9(5):244-252. |
| Zhou X, Ye Y, Sun Y, Privratsky B, Wang W, Birnbaumer L, Wu M, Singh BB. TRPC1 deficiency impairs host defense and proinflammatory responses to bacterial infection by regulating PKC signaling Molecular and Cellular Biology 2015 Jan;35(16):2729-2739. |
| Sun Y, Birnbaumer L and Singh BB. TRPC1 regulate calcium-activated chloride channels in salivary gland tissues and cells Journal of Cellular Physiology 2015 Jan;230(11):2848-2856. |
| Selvaraj S, Singh BB, Bollensdorff C, Suwaidi J AL, and Yacoub M. A critical role of TRPC1-ORAI1-STIM1 mediated store-operated calcium entry in cardiac hypertrophy Journal of the American College of Cardiology 2015 Jan;65(10_S). |
| Selvaraj S, Sun Y, Sukumaran P, Singh BB. Resveratrol-activates autophagic cell death in cancer cells via down regulation of TRPC1-STIM1 and the mTOR pathway Molecular Carcinogenesis 2015 Jan;55(5):818-831. |
| Sun Y, Chauhan A, Sharma J, Singh BB, Mishra BB. Inhibition of store-operated Ca2+ entry in microglia by helminth antigens Journal of Neuroinflammation 2014 Dec;11(1). |
| Chauhan A, Sun Y, Pani B, Fredice Q, Sharma J, Singh BB, Mishra BB. Helminth-induced suppression of macrophage activation is correlated with inhibition of calcium channel activity. e101023 doi:10.1371 PLOS1 2014 Jul;11(9). |
| Sun Y, Sukumaran P, Varma A, Derry S, Shamoun AE and Singh BB. Cholesterol-induced activation of TRPM7 regulates cell viability, proliferation, and migration of human cancer cells Biochim Biophys Acta 2014 Jan;1843(9):1839-1850. |
| Sun Y, Sukumaran P, and Singh, BB. Physiological function and characterization of TRPCs in non-excitable and excitable cells Cells 2014 Jan;3(2):455-475. |
Teaching
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| Date | Description | Institution | # Students |
| - Present | BIMD 503 | ||
| Delivered 1 lecture and worked with BIMD 503 module graduate students for a week (7 contact hours). Also was involved in evaluating and public speaking. | |||
| - Present | Membership on Supervising Committee | University of North Dakota | |
Grants
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Federal |
|
| Funding Agency | NIH, NIDCR |
| Title | Epigenetic regulation in Sjogerns syndrome |
| Status | Active |
| Period | 8/2017 - 7/2022 |
| Role | Principal Investigator |
| Grant Detail | The long-term goal of this project is to elucidate the role of epigenetic regulations in the onset of Sjogren`s Syndrome. |
| Funding Agency | NIH, NIGMS |
| Title | Center for Excellence In-Host Pathogen Interactions (relinquished as moved to UT Health San Antonio) |
| Status | Active |
| Period | 5/2016 - 5/2021 |
| Role | Principal Investigator |
| Grant Detail | The long-term goal of this program project grant (COBRE) is to establish a center for host pathogen interaction. |
| Funding Agency | NIH, NIDCR |
| Title | TRPC1 calcium and exocrine function |
| Status | Active |
| Period | 7/2005 - 9/2020 |
| Role | Principal Investigator |
| Grant Detail | The long term-goal of this project is to identify and elucidate the mechanism of the role of TRPC1 function in salivary glands secretion and regulation. |
| Funding Agency | NIH, NIHES |
| Title | Environmental toxins and stem cell epigenetic remodeling |
| Status | Complete |
| Period | 9/2012 - 8/2018 |
| Role | Co-Investigator |
| Grant Detail | The long-term goal of this project is to identify the relationship between environmental toxins and epigenetic regulation in Parkinson`s disease. |
| Funding Agency | NIH, NIAID |
| Title | Lung innate immunity against bacterial infection |
| Status | Active |
| Period | 9/2012 - 8/2018 |
| Role | Co-Investigator |
| Grant Detail | The goal of this project is to determine the role of ATG-7-mediated autophagy in protection against gram-negative bacteria in bacterial clearance by alveolar macrophages. |
| Funding Agency | NIH, NIDCR |
| Title | Galectins as novel alarmins in salivary gland inflammation |
| Status | Complete |
| Period | 7/2015 - 6/2018 |
| Role | Principal Investigator |
| Grant Detail | The long-term goal of this project is to identify the role of alarmins in regulating inflammation. |
| Funding Agency | NIH NIAID |
| Title | Role of STIM1 in E.coli Pneumonia sepsis. |
| Status | Complete |
| Period | 12/2015 - 11/2017 |
| Role | Co-Investigator |
| Grant Detail | (Subcontract $70,000)The long-term goal of this project is to evaluate the role of STIM1 and calcium entry in sepsis. |
| Funding Agency | Infrastructure Improvement Program (IIP) - Equipment Grants ND-EPSCoR |
| Title | Calcium Imaging Facility at University of North Dakota |
| Status | Complete |
| Period | - Present |
| Role | Principal Investigator |
| Grant Detail | |