Departments & Divisions
Professor and chair
Dr. David L. Cochran is a graduate of the University of Virginia and received his DDS, MS and Ph.D. in Biochemistry from the Medical College of Virginia. He was trained in Periodontology at the Harvard School of Dental Medicine where he also obtained a second master's degree. He recently received an Honorary Doctorate from the University of Bern in Switzerland.
Dr. Cochran is currently professor and chairman of the Department of Periodontics at UT Health San Antonio School of Dentistry. Prior to his appointment at San Antonio, Dr. Cochran was director of Postgraduate Periodontics at the Medical College of Virginia. Dr. Cochran is a member of many professional dental organizations and is a Diplomate of the American Board of Periodontology. He is a fellow of the American College of Dentistry and the International College of Dentistry.
Dr. Cochran has published numerous scientific articles and abstracts on various periodontal, biochemistry, and implant topics. He has received awards for his research work at both the national and international levels. Dr. Cochran is an active basic science and clinical researcher who has received funding from both the NIH-NIDCR and private industry.
Funding Agency NIH Title Small Molecule Mediated Restoration of Periodontal Homeostasis Through the YAP1 Pathway Status Active Period 4/2017 - 3/2019 Role Consultant Grant Detail This study will attempt to discover the role of inflammation-related microRNA cluster 23-27-24. Dr. Cochran will consult on the research involving these proteins in a rodent model at Texas A&M Baylor College of Dentistry on the Emdogain applications. Funding Agency NIH Title National Dental Practice-Based Research Network: Southwest Regional Node Status Active Period 4/2012 - 3/2019 Role Principal Investigator Grant Detail Dr. Cochran serves as the Regional Director and provides administrative oversight of all regional activities and strategic management of the regional component in alignment with the national network. In addition, he directly supports study idea generation, concept development, regulatory oversight, and communications. In his role as the Network Director, he plays an active role in recruitment of dental practitioners, planning of meetings, and implementation of research studies and will contribute to the writing of the publications and dissemination presentations. Dr. Cochran serves as the primary liaison between all collaborating partners (STOHN and the University of Alabama). Funding Agency NIH Title The National Dental PBRN Status Active Period 4/2012 - 3/2019 Role Principal Investigator Grant Detail Funding Agency Army Med Research Acquisition Activity Title Armed Forces Institute for Regeneration Medicine (AFIRM) II Program Status Complete Period 1/2014 - 12/2017 Role Co-Investigator Grant Detail To design and develop injectable, settable bone grafts augmented with recombinant human growth factors for regeneration of calvarial bone. To design and develop injectable, settable bone grafts augmented with rhGDF-5 for regeneration of alveolar bone that supports restored dentition. To design and develop injectable, settable bone grafts with initial mechanical properties approaching those of trabecular bone and augmented with rhGDF-5 for regeneration of load-bearing bone that supports masticatory forces. Dr. Cochran will assist with the preclinical studies and with the interpretation and analysis of the data.
Funding Agency Genetics Institute Title Pilot Study Evaluation of rhBMP-2/Absorbable Collagen Sponge Device for Alveolar Ridge Preservation or Augmentation Status Complete Period - Present Role Principal Investigator Grant Detail Funding Agency OraPharma Title Multicenter Phase III Trial of Minocycline Periodontal Therapeutic System Status Complete Period - Present Role Principal Investigator Grant Detail Funding Agency Genetics Institute Title Bone Morphogenic Protein-2/Healing of Osseous Defects Surrounding Dental Implants Status Complete Period - Present Role Principal Investigator Grant Detail Funding Agency Straumann, Inc. Title The Use of ITI SLA Implants as Immediate Implants in Extraction Sites, A Pilot Study Status Complete Period - Present Role Principal Investigator Grant Detail Funding Agency Organogenesis, Inc. Title A Clinical Trial to Evaluate CelTx? (Apligraf?) as an Alternative to Tissue from the Palate to Enhance Oral Soft Tissue Regeneration and Would Healing Status Complete Period 3/2008 - 1/2029 Role Principal Investigator Grant Detail CelTx? is a two-layered sheet, made from purified cow tendon collagen, living human cells, and a substance to maintain (feed) the cells until they are placed on a wound. This is a research study to evaluate the safety and effectiveness of an experimental therapy called CelTx? in the treatment of shrinkage of the gums around teeth. This study compares conventional therapy (placement of tissue from the roof the mouth on gum tissue at the area of shrinkage) to treatment with CelTx? (placed at the area of shrinkage). The purpose of this research study is to evaluate the safety and effectiveness of treating gum shrinkage with CelTx? compared to conventional treatment (tissue from the roof of your mouth). Funding Agency LaunchPad Title The Use of a Bone Adhesive to Secure Dental Implants Status Active Period 10/2017 - 4/2019 Role Co-Investigator Grant Detail The purpose of the proposed study is to demonstrate that Tetranite (TN) can provide immediate stability to dental implants placed in oversized osteotomies, that it can maintain implant stability over time, and that the material is resorbed and replaceed with bone during the course of the nine-month study. Funding Agency ITI Foundation Title Tetranite Bone Adhesive Device Used to Stabilize Dental Implants in Bone Status Active Period 10/2017 - 4/2019 Role Contributor Grant Detail The purpose of the proposed study is to demonstrate that Tetranite (TN) can provide immediate stability to dental implants placed in oversized osteotomies, that it can maintain implant stability over time, and that the material is resorbed and replaced with bone during the course of the nine-month study. Funding Agency ITI Foundation Title The Effect of Osteogain on New Bone Formation in a Critical-sized, Intra-oral Defect Model in Minipigs Status Active Period 1/2017 - 4/2018 Role Principal Investigator Grant Detail To determine the effect of Osteogain mixed with commonly-used bone substitutes (Xenograft, Synthetics and Allograft) on bone regeneration in critical-sized defects.
Alkan EA, Mau LP, Schoolfield J, Guest GF, Cochran DL. Prevalence of Dental Implants and Evaluation of Peri-implant Bone Levels in Patients Presenting to a Dental School: A Radiographic Cross-Sectional 2-Year Study; 2018 Feb. (Int J Oral Maxillofac Implants; vol. 33, no. 1). Talley AD, Kalpakci KN, Zienkiewicz K, Cochran DL, Guelcher S. Local Delivery of rhBMP-2 from a Compression-Resistant Graft in a Canine Lateral Ridge Augmentation Model; 2015 Jan. (2015 American Institute of Chemical Engineers (AIChE) CONFERENCE). Cochran DL. Clinical Relevance of Integrated Developmental Research for Dental Implants; 2014 Sep. (J Dent Res). Osawa G1, Nakaya H, Mealey BL, Kalkwarf K, Cochran DL. Specialty education in periodontics in Japan and the United States: comparison of programs at Nippon Dental University Hospital and the University of Texas Health Science Center at San Antonio; 2014 Mar. (Journal of Dental Education; vol. 78, no. 3).
George Kay, Michael Brown, Michael A. Pikos, Alan Pollack, Paul Fugazzotto, Bruce R. Donoff, Richard J. Miron, David L. Cochran. Next-Generation Osteoconductive Resorbable Bone Adhesives: Tetranite. In: Miron RJ and Zhang Y. Next-Generation Biomaterials for Bone & Periodontal Regeneration. Batavia, IL: Quintessence Publishing Co, Inc; 2019. p. 121-139. Richard J. Miron, Anton Sculean, David L. Cochran, Nikos Donos, James Deschner, Michel Dard, Yufeng Zhang, Adrian Kasaj, Yoshinori Shirakata and Dieter D. Bosshardt. Enamel Matrix Derivative: Preclinical Biologic Background. In: Richard J. Miron and Yufeng Zhang. Next-Generation Biomaterials for Bone & Periodontal Regeneration. Batavia, IL: Quintessence Publishing Co, Inc; 2019. p. 197-210.
Cochran DL, Jones AA, Sugita R, Brown MC, Guda T, Prasad H, Ong JL, Pollack A, Kay GW. Immediate Dental Implant Stabilization in a Canine Model Using a Novel Mineral-Organic Adhesive: Four Month Results IJOMI 2019 Sep;. Cochran DL. Impact of Er:YAG Laser on Wound Healing Following Non-surgical therapy. A Pilot Study Clin Exper Dent Res 2019 Jun;. Ghazal S, Huynh-Ba G, Aghaloo T, Dibart S, O'Neal R, Cochran DL. Randomized Controlled Multicenter Clinical Study Evaluating Crestal Bone Level Change of Narrow-Diameter Versus Standard-Diameter Ti-Zr Implants for Single Tooth Replacement in Anterior and Premolar Region The International Journal of Oral & Maxillofacial Implants 2019 Jun;34(3):708-718. Cochran DL, Gordan VV. Leadership in Practice-based Research: The National Dental PBRN J Dent 2019 May;. Mau JL, Grodin E, Lin JJ, Chen MC, Ho C, Cochran D. A comparative randomized prospective, two-center clinical study to evaluate the clinical and esthetic outcomes of two different bone grafting techniques in early implant placement Journal of Periodontology 2019 Mar;90(3):247-255. Cochran DL, Garrett P. Hard and Soft Tissue Evaluation of Titanium Dental Implants and Abutments with Nanotubes in Canines 2019 Mar;. Cochran DL, Ghazal S. A Randomized, Controlled, Multi-center Clinical Study Evaluating the Crestal Bone Level Change of SLActive Bone Level 3.3 mm Implants Compared to SLActive Bone Level 4.1 mm bone level Implants for Single Tooth Replacement IJOMI 2019 Mar;. Roehling S, Gahlert M, Janner S, Meng B, Woelfler H, Cochran DL. Ligature-Induced Peri-implant Bone Loss Around Loaded Zirconia and Titanium Implants The International Journal of Oral & Maxillofacial Implants 2019 Mar;34(2):357-365. Cochran DL, Berger MB. Human Osteoblasts Exhibit Sexual Dimorphism in Their Response to Estrogen on Microstructured Titanium Surfaces Biol Sex Diff 2018 Jul;. McCauley JL, Leite RS, Gordan VV, Fillingim RB, Gilbert GH, Meyerowitz C, Cochran D, Rindal DB, Brady KT. Opioid Prescribing and Risk Mitigation Implementation in the Management of Acute Pain: Results from the National Dental PBRN Journal of the American Dental Association 2018 May;149(5):353-362. Talley AD, Boller LA, Kalpakci KN, Shimko DA, Cochran DL, Guelcher SA. Injectable, compression-resistant polymer/ceramic composite bone grafts promote lateral ridge augmentation without protective mesh in a canine model Clin Oral Impl Res 2018 Apr;(4):592-602. Janner SFM, Gahlert M, Bosshardt DD, Roehling S, Milz S, Higginbottom F, Buser D, Cochran DL. Bone response to functionally loaded, two-piece zirconia implants: A preclinical histometric study Clin Oral Implants Res 2018 Mar;29(3):277-289. Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM, Chen S, Cochran DL, Derks J, Figuero E, Hammerle CHF, Heitz-Mayfield LJA, Huynh-Ba G, Iacono V, Koo KT, Lambert F, McCauley L, Quirynen M, Renvert S, Salvi GE, Schwarz F, Tarnow D, Tomasi C, Wang HL, Zitzmann N. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions J Periodontol 2018 Mar;89:S313-S318. Cochran DL, Aklan E. Prevalence of Dental Implants and Peri-Implant Bone Level in Patients Presenting to a Dental School: A Radiographic Cross-sectional 2-Year Study IJOMI 2018 Feb;. Mia Rakic, Pablo Galindo-Moreno, Alberto Monje, Sandro Radovanovic, Hom-Lay Wang, David Cochran, Anton Sculean, Luigi Canullo. How frequent does peri-implantitis occur? A systematic review and meta-analysis Clinical Oral Innvestigations 2017 Dec;. Tallarico M, Meloni SM, Xhanari E, Pisano M, Cochran DL. Minimally Invasive Sinus Augmentation Procedure using a Dedicated Hydraulic Sinus Lift Implant Device: A Prospective Case Series Study on Clinical, Radiologic, and Patient-Centered Outcomes The International Journal of Periodontics & Restorative Dentistry 2017 Feb;37(1):125-135. Marco Tallarico, Silvio Mario Meloni, Hom-Lay Wang, David L Cochran, Alberto Monje, Luigi Canullo. Classification systems for peri-implantitis: a narrative review with a proposal of a new evidence-based etiology codification The International Journal of Oral & Maxillofacial Implants (Manuscript in Submission) 2017 Jan;. Sasada Y, Cochran DL. Implant-Abutment Connections: A Review of Biologic Consequences and Peri-implantitis Implications The International Journal of Oral & Maxillofacial Implants 2017 Jan;32(6):1296-1307. Tallarico M, Cochran DL, Xhanari E, Dellavia C, Canciani E, Mijiritsky E, Meloni SM. Crestal sinus lift using an implant with an internal L-shaped channel: 1-year after loading results from a prospective cohort study European Journal of Oral Implantology 2017 Jan;10(3):325-336. Janner SF, Bosshardt DD, Cochran DL, Chappuis V, Huynh-Ba G, Jones AA, Buser D. The influence of collagen membrane and autogenous bone chips on bone augmentation in the anterior maxilla: a preclinical study.(Epub Ahead of Print) Clinical Oral Implants Research 2016 Dec;(28):1368-1380. Cochran DL, Stavropoulos A, Obrecht M, Pippenger B, Dard M. A Comparison of Tapered and Nontapered Implants in the Minipig The International Journal of Oral & Maxillofacial Implants 2016 Nov;31(6):1341-1347. Miron RJ,2, Sculean A, Cochran DL, Froum S, Zucchelli G, Nemcovsky C, Donos N, Lyngstadaas SP, Deschner J, Dard M, Stavropoulos A, Zhang Y, Trombelli L, Kasaj A, Shirakata Y, Cortellini P, Tonetti M, Rasperini G, Jepsen S, Bosshardt DD. Twenty years of enamel matrix derivative: the past, the present and the future J Clin Periodontol 2016 Aug;43(8):668-683. Albrektsson T, Canullo L, Cochran DL, De Bruyn H. "Peri-Implantitis": A Complication of a Foreign Body or a Man-Made "Disease". Facts and Fiction Clin Implant Dentistry and Related Research 2016 Jun;00:1-10. Cochran DL; Oh TJ, Mills MP, Clem DS, McClain PK, Schallhorn RA, McGuire MK, Scheyer ET, Giannobile WV, Reddy MS, Abou-Arraj RV, Vassilopoulos PJ, Genco RJ, Geurs NC, Takemura A. A Randomized Clinical Trial Evaluating rh-FGF-2/β-TCP in Periodontal Defects J Dent Res 2016 May;95(5):523-530. Mau L-P, Cheng W-C, Chen J-K, Shieh Y-S, Cochran DL, Huang R-Y. Curcumin Ameliorates Alveolar Bone Destruction of Experimental Periodontitis by Modulating Osteoclast Differentiation, Activation and Function Journal of Functional Foods 2016 Apr;(22):243-256. Stravropoulos A, Cochran DL, Obrecht M, Pippenger BE, Dard M. Effect of Osteotomy Preparation on Osseointegration of Immediately Loaded, Tapered Dental Implants Adv Dent Res 2016 Mar;28(1):34-41. Talley AD, Kalpakci KN, Shimko DA, Zienkiewicz KJ, Cochran DL, Guelcher SA. Effects of Recombinant Human Bone Morphogenetic Protein-2 Dose and Ceramic Composition on New Bone Formation and Space Maintenance in a Canine Mandibular Ridge Saddle Defect Model Tissue Eng Part A 2016 Mar;22(5-6):469-479. Huynh-Ba G, Meister DJ, Hoders AB, Mealey BL, Mills MP, Oates TW, Cochran DL, Prihoda TJ, McMahan CA. Esthetic, clinical and patient-centered outcomes of immediately placed implants (Type 1) and early placed implants (Type 2): preliminary 3-month results of an ongoing randomized controlled clinical trial Clinical Oral Implants Research 2016 Feb;27(2):241-52. French D, Cochran DL, Ofec R. Retrospective Cohurt Study of 4.591 Straumann Implants Placed in 2,060 Patients in Private Practice with up to 10-year Follow-up: The Relationship Between Crestal Bone Level and Soft Tissue Condition Int J Oral Maxillofac Implants 2016 Jan;31(6):168-178. Vierra M, Mau LP, Huynh-Ba G, Schoolfield J, Cochran DL. A lateral ridge augmentation study to evaluate a synthetic membrane for guided bone regeneration: an experiment in the canine mandible Clin Oral Implants Res 2016 Jan;27(1):73-82. Miron RJ, Chandad F, Buser D, Sculean A, Cochran DL, Zhang Y. Effect of Enamel Matrix Derivative Liquid on Osteoblast and Periodontal Ligament Cell Proliferation and Differentiation J Periodontol 2016 Jan;87(1). Cochran DL, Miron R. 20 Years of Enamel Matrix Derivative: The Past, the Present and the Future J Clin Perio 2015 Nov;. Sung CE, Cochran DL, Cheng WC, Mau LP, Huang PH, Fan WH, Shieh YS, Huang RY. Preoperative assessment of labial bone perforation for virtual immediate implant surgery in the maxillary esthetic zone: A computer simulation study J Am Dent Assoc 2015 Nov;146(11):808-819. Huang RY, Cochran DL, Cheng WC, Lin MH, Fan WH, Sung CE, Mau LP, Huang PH, Shieh YS. Risk of lingual plate perforation for virtual immediate implant placement in the posterior mandible: A computer simulation study J Am Dent Assoc 2015 Oct;146(10):735-742. Villar CC, Zhao XR, Livi CB, Cochran DL. Effect of living cellular sheets on the angiogenic potential of human microvascular endothelial cells J Periodontol 2015 May;86(5):703-712. Meng B. Cochran DL, Qing H. Direct Drilling and GBR for Implant Placement in Anterior Maxilla with Horizontal Bone Defect: a Step by Step Correcting Direction Drilling Technique International Journal of Clinical Case Reports 2015 Apr;5(15):1-5. Cochran DL. Emerging regenerative approaches for periodontal reconstruction: a systematic review from the AAP Regeneration Workshop J Periodontol 2015 Feb;86(2 Sup):134-152. Cochran DL, Cobb CM, Bashutski JD, Chun YP, Lin Z, Mandelaris GA, McAllister BS, Murakami S, Rios HF. Emerging regenerative approaches for periodontal reconstruction: a consensus report from the AAP Regeneration Workshop J Periodontol 2015 Feb;86(2 Sup):153-156. Rios HF, Bashutski JD, McAllister BS, Murakami S, Cobb CM, Chun YP, Lin Z, Mandelaris GA, Cochran DL. Emerging Regenerative Approaches for Periodontal Reconstruction: Practical Applications From the AAP Regeneration Workshop Clin Adv Periodont 2015 Feb;5(1):40-46. Cochran DL, Stavropoulos A. Underpreparation of the Implant Socket May Compromise Osseointegration of a Novel Tapered Implant Subjected to Immediate Loading J Dent Res 2015 Jan;. Cochran DL, Obrecht M, Weber K, Dard M, Bosshardt D, Higginbottom FL, Wilson TG, Jones AA. Biologic width adjacent to loaded implants with machined and rough collars in the dog Int J Periodontics Restorative Dent 2014 Nov;34(6):773-779. Caram SJ, Huynh-Ba G, Schoolfield JD, Jones AA, Cochran DL, Belser UC. Biologic width around different implant-abutment interface configurations. A radiographic evaluation of the effect of horizontal offset and concave abutment profile in the canine mandible The International Journal of Oral and Maxillofacial Implants 2014 Sep;29(5):1114-1122. Better H, Slavescu D, Barbu H, Cochran DL, Chaushu G. Minimally invasive sinus lift implant device: a multi center safety and efficacy trial preliminary results Clin Implant Dent Relat Res 2014 Aug;16(4):520-526. Coomes AM, Mealey BL, Huynh-Ba G, Barboza-Arguello C, Moore WS, Cochran DL.
. Buccal bone formation after flawless extraction: a randomized, controlled clinical trial comparing recombinant human bone morphogenetic protein 2/absorbable collagen carrier and collagen sponge alone J Periodontol 2014 Apr;85(4):525-535. Scheyer ET, Nevins ML, Neiva R, Cochran DL, Giannobile WV, Woo SB, King WN, Spitznagel JK, Bates D, McGuire MK. Generation of site-appropriate tissue by a living cellular sheet in the treatment of mucogingival defects J Periodontol 2014 Apr;85(4):57-64. Lin M, Mau L, Cochran DL, Shieh Y, Huang P, Huang R. Risk assessment of inferior alveolar nerve injury for immediate implant placement in the posterior mandible: A virtual implant placement study Journal of Dentistry 2014 Mar;42(3):263-270. Jackson A, Lemke RR, Hatch JP, Salome N, Gakunga PT, Cochran DL. A comparison of stability between delayed versus immediately loaded orthodontic palatal implants Journal of Esthetic and Restorative Dentistry 2008 Mar;20(3):174-184.