Departments & Divisions
Dr. David Dean's research activities focus on three main areas.
1) The first area of interest involves examining how osteoblasts interact with titanium implant surfaces and the role of arachidonic acid metabolites (prostaglandin E2, arachidonic acid, and nonsteroidal antiinflammatory drugs) in regulating osteoblast response. The laboratory has developing methods for measuring changes in gene expression during the first 3-6 hours of culture on an implant surface so that it is possible to examine some of the very earliest cell responses to titanium or other biomaterials.
2) A second area focuses on isolating and characterizing wear debris particles from resin, wear machine fluids, and tissues. The laboratory is actively working on fractionating wear debris particles into micron, sub-micron, and nanometer size ranges. After fractionation, particle preparations will be tested for their effect on osteoblasts; changes in gene expression, as well as differentiation, proliferation, and local factor production, will be assessed.
3) The third area of research is a joint effort with colleagues in Biomedical Engineering at UTSA, Carnegie Mellon University, and Brooke Army Medical Center/Institute for Surgical Research to develop tissue engineering scaffolds for bone repair. The research focuses on developing new materials for regenerating large segments of bone lost due to trauma such as encountered on the battlefield.
Funding AgencySan Antonio Life Sciences InstituteTitleEstablishment of pancreatic microenvironment ex vivo to grow and preserve pancreatic isletsStatusActivePeriod9/2014 - 8/2015RoleCo-InvestigatorGrant Detail
Kim J, McBride S, Fulmer M, Harten R, Garza RZ, Dean DD, Sylvia VL, Doll B, Gruskin E, Hollinger JO . Fiber-reinforced Calcium Phosphate Cement Formulations for Cranioplasty Applications: A 52 Week Duration Preclinical Rabbit Calvaria Study Journal of Biomedical Materials Research: Part B: Applied Biomaterials 2012 Jan;100:1170-1178.
Perrien DS, Alvarez-Urena P, Dean DD, Young CS, Lynch SE, ? Hollinger JO. Percutaneous Injection of Augment? Injectable Bone Graft (rhPDGF-BB and ?-Tricalcium Phosphate (?-TCP)/Bovine Type I Collagen Matrix) Increases Vertebral Bone Mineral Density in Geriatric Female Baboons Spine 2012 Jan;.Kim J, McBride S, Tellis B, Alvarez-Urena P, Song YH, Dean DD, Sylvia VL, Elgendy H, Ong JL, Hollinger JO. Rapid-prototyped PLGA/b-tcp/Hydroxyapatite Nanocomposite Scaffolds in a Rabbit Femoral Defect Model Biofabrication 2012 Jan;4.