The Distinguished Medical Alumnus Award is the highest honor the Alumni Association bestows upon a graduate of the Long School of Medicine. It is given each year to a graduate who has demonstrated the highest principles of the medical profession and has made outstanding contributions to society and the field of medicine through patient care, basic research, clinical research, and/or health services administration. The recipient of the award receives a framed certificate.
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| Year Honored | First Name Last Name | Specialty | Class of | City/State |
| 1991 | Ira J. Chasnoff, M.D. | Pediatrics | Class of 1973 | Chicago, IL |
| 1992 | James C. Martin, M.D. | Family Practice | Class of 1973 | San Antonio, TX |
| 1993 | Chris P. Johnson, M.D. | Pediatrics | Class of 1978 | San Antonio, TX |
| 1994 | Sandra Sabatini, M.D. | Nephrology | Class of 1974 | Lubbock, TX |
| 1995 | Richard J. Gray, M.D. | Cardiology | Class of 1970 | St. Paul, MN |
| 1996 | Leah Raye Mabry, M.D. | Family Practice | Class of 1982 | San Antonio, TX |
| 1997 | Clyde A. Helms, M.D. | Radiology | Class of 1972 | Durham, NC |
| 1998 | C. Nanette Clare, M.D. | Pathology | Class of 1975 | San Antonio, TX |
| 1999 | Harold Timboe, M.D. | Family Practice | Class of 1978 | Bentonville, AR |
| 2000 | Richard A. Becker, M.D. | Endocrinology | Class of 1971 | San Antonio, TX |
| 2001 | Stanley Culotta, M.D. | Family Practice | Class of 1978 | San Antonio, TX |
| 2002 | David R. Schmidt, M.D. | Orthopaedics/Family Practice | Class of 1980 | San Antonio, TX |
| 2003 | Joyce G. Schwartz | Pathology | Class of 1980 | San Antonio, TX |
| 2004 | Martha Medrano, M.D. | Psychiatry | Class of 1981 | San Antonio, TX |
| 2005 | Ronald M. Stewart, M.D. | Surgery/General | Class of 1985 | San Antonio, TX |
| 2006 | Patricia Sulak, M.D. | Ob/Gyn | Class of 1980 | Temple, TX |
| 2007 | Joel Tsevat, M.D. | Internal Medicine | Class of 1983 | Cincinnati, OH |
| 2008 | Lois Bready, M.D. | Anesthesiology | Class of 1977 | San Antonio, TX |
| 2009 | Jacqueline Pugh, M.D. | Internal Medicine/Epidemiology | Class of 1981 | San Antonio, TX |
| 2010 | Everardo Cobos, M.D. | Oncology | Class of 1981 | Lubbock, TX |
| 2011 | Roland Goertz, M.D. | Family Medicine | Class of 1981 | Waco, TX |
| 2012 | James L. Holly, M.D. | Family Medicine | Class of 1973 | Beaumont, TX |
| 2013 | William W. Hinchey, M.D. | Pathology | Class of 1978 | San Antonio, TX |
| 2014 | Thomas L. Matthews, M.D. | Psychiatry | Class of 1997 | San Antonio, TX |
| 2015 | Larry Carver, M.D. | Surgery/Neurological | Class of 1980 | Houston, TX |
| 2016 | Steven J. Cyr, M.D. | Orthopaedics | Class of 1996 | San Antonio, TX |
| 2017 | Janet P. Realini, M.D. | Family Medicine | Class of 1978 | San Antonio, TX |
| 2018 | Michael W. Brennan, M.D. | Ophthalmology | Class of 1978 | Burlington, NC |