Saikumar P. Opposing roles of Smad2 and Smad3 in the regulation of growth and invasion of TNBC through TMEPAI; 2017 Apr. (Proceedings of the AACR). Prajjal K. Singha, Srilakshmi Pandeswara, Manjeri A. Venkatachalam and Pothana Saikumar. TGFβ-Smad3-TMEPAI axis drives the Tumor Progression of Triple Negative Breast Cancer: AACR; 2017 Jan. (Cancer Reseaerch). Saikumar P. TMEPAI a novel therapeutic target in triple Negative breast cancer prevention and therapy; 2016 Nov. (NCRI Conference). Saikumar P. Targeting TMEPAI/PMEPA1 inhibited triple negative breast cancer cell growth and metastasis through growth suppressive TGF-beta signaling; 2016 May. (Cancer Res; vol. 76, no. 9 Sup). Singha PK K, Pandeswara S, Venkatachalam MA A and Saikumar P. Interplay of Smad2 and Smad3 during TGF-b induced TMEPAI/ PMEPA1 mediated triple negative breast cancer cell growth; 2016 May. (Cancer Res). Singha PK K, Pandeswara S, Venkatachalam MA A and Saikumar P. Targeting TMEPAI/PMEPA1 inhibits triple negative breast cancer cell growth and metastasis by enhancing growth suppressive TGF-I? signaling; 2016 Apr. (Cancer Res; vol. 76). Singha PK, Pandeswara S, Venkatachalam MA and Saikumar P. Role of TMEPAI-PTEN-PI3K/Akt Axis in TGF-beta mediated Growth and Metastasis of Breast Cancer Cells; 2015 Aug. (Cancer Res; vol. 75). Singha PK, Pandeswara S, Venkatachalam MA and Saikumar P. Divergent effects of Smad2 and Smad3 on TGF-beta mediated breast cancer cell growth and expression of TMEPAI/PMEPA1; 2015 Aug. (Cancer Res; vol. 75). Singha PK, Pandeswara S, Venkatachalam MA, and Saikumar P. Manumycin A derived nanoparticle induced cytoplasmic vacuolation mediated cell death in triple negative breast cancer; 2015 May. (Cancer Research; vol. 75, no. 9 Sup). Prajjal Kanti Singha, Nandita Mishra, Rekha Kar, Srilakshmi Pandeswara, Manjeri A. Venkatachalam, Pothana Saikumar. Targeting LC3-SQSTM1 (p62) signaling axis to treat apoptosis-resistant and metastatic breast cancers; 2010 Jan. (AACR). Singha PK, Pandeswara S, Venkatachalam MA, Saikumar P. TMEPAI, a Novel Prognostic Marker for TGF-β Dependency of Metastatic Breast Cancers: Converts Tumor Suppressive TGF-β into a Tumor Promoter; 2010 Jan. (SABCS Annual Meeting). Saikumar P, Mikhailov VI, Mikhailova M, Venkatachalam MA, Kar R. Bax mediated release of apoptosis inducing factors requires its dissociation from the inner mitochondrial membrane; 2004 Jan. (FASEB J; vol. 18, no. 8). Saikumar P, Mikhailov VI, Mikhailova M, Venkatachalam MA. Rapid cell death in Bcl-2 overexpressing rat proximal tubule cells exposed to cold and rewarming; 2003 Jan. (J Am Soc Nephrol; vol. 14). Saikumar P, Mikhailova M, Mikhailov VI, Venkatachalam MA, Denton ML. Caspase activation through formation of protein complexes during hypoxia or ATP depletion; 2002 Jan. (FASEB J; vol. 16, no. 4). Mikhailov VI, Mikhailova M, Venkatachalam MA, Saikumar P. Bax dependent release of apoptogenic factors from mitochondria by t-Bid; 2002 Jan. (J Am Soc Nephrol; vol. 13). Mikhailova M, Mikhailov VI, Denton ML, Dong Z, Venkatachalam MA, Saikumar P. Apoptotic protein complexes in hypoxic rat kidney proximal tubule cells; 2001 Jan. (J Am Soc Nephrol; vol. 12).
Prajjal Singha , Sreelakshmi Pandeswara , Hui Geng , Rongpei Lan , Manjeri Venkatachalam , Albert Dobi , Shiv Srivastava, Saikumar P. Increased Smad3 and reduced Smad2 levels mediate the functional switch of Transforming Growth Factor-β from growth suppressor to growth and metastasis promoter through TMEPAI/PMEPA1 in triple negative breast cancer Genes and Cancer 2019 Jul;. Lan, R, Geng, H, Singha, P, Saikumar P, Bottinger, EP, Weinberg, JM, Venkatachalam MA. Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI Journal of the American Society of Nephrology 2016 Nov;27(11):3356-3367. Gonzales CB, De La Chapa JJ, Saikumar P, Singha PK, Dybdal-Hargreaves NF, Chavez J, Horning AM, Parra J, Kirma NB. Co-targeting ALK and EGFR parallel signaling in oral squamous cell carcinoma Oral Oncology 2016 Aug;59(08):12-19. Geng H, Lan R, Singha PK, Gilchrist A, Weinreb PH, Violette SM, Weinberg JM, Saikumar P, Venkatachalam MA.
. Lysophosphatidic Acid Increases Proximal Tubule Cell Secretion of Profibrotic Cytokines PDGF-B and CTGF through LPA2- and Gaq-Mediated Rho and av?6 Integrin-Dependent Activation of TGF-? Am J Pathol 2012 Jan;181(4):1236-1249.
Rongpei Lan, Hui Geng, Yoon Hwang, Pramod Mishra,
Wayne L.Skloss, Eugene A. Sprague, Pothana Saikumar, and Manjeri
. A Novel Wounding Device Suitable for Quantitative Biochemical Analysis of Wound Healing and Regeneration of Cultured Epithelium Wound Repair and Regeneration 2010 Jan;18:159-167. Kar R, Mishra N, Singha P, Venkatachalam MA and Saikumar P. Mitochondrial Remodeling Following Fission Inhibition by 15d-PGJ2 Involves Molecular Changes in Mitochondrial Fusion Protein OPA1 Biochem Biophys Res Comm 2010 Jan;399(4):548-554. Mishra N, Kar R, Singha PK, Venkatachalam MA, McEwen DG, Saikumar P. Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2 Biochem Biophys Res Commun 2010 Jan;395(1):17-24. Geng, H, Lan, R, Wang, G, Siddiqi, AR, Naski MC, Brooks, AI, Barnes JL, Saikumar P, Weinberg, JM, Venkatachalam MA. Inhibition of autoregulated TGFβ signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemia Am J Pathol 2009 Jan;174(4):1291-1308. Kar R, Singha PK, Venkatachalam MA, Saikumar P. A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells Oncogene 2009 Jan;28(28):2556-2568. Saikumar P, Mikhailova M, Pandeswara SL. Regulation of caspase-9 activity by differential binding to the apoptosome complex Front Biosci 2007 Jan;12:3343-3354. Mikhailov V, Mikhailova M, Degenhardt K, Venkatachalam MA, White E, Saikumar P. Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release J Biol Chem 2003 Jan;278(7):5367-5376. Mikhailov V, Mikhailova M, Pulkrabek DJ, Dong Z, Venkatachalam MA, Saikumar P. Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane J Biol Chem 2001 Jan;276(21):18361-18374.
Saikumar P, Singha PK, Pandeswara S, and Venkatachalam MA. Notch inhibitors relieve growth suppression by TGF-β and promote growth and metastasis of triple negative breast cancers Cancer Research 2018 Jan;.
Venkatachalam MA, Griffin KA, Lan R, Geng H, Saikumar P, Bidani AK. Acute kidney injury: a springboard for progression in chronic kidney disease Am J Physiol Renal Physiol 2010 Jan;298(5):F1078-F1094.