Partial Irradiation and Sequential vs. Concurrent Chemo Early Breast Cancer
Breast conserving therapy (BCT), which consists of wide local excision of the tumor followed by 6 weeks of whole breast irradiation (WBI) is integral to the management of breast cancer. Evidence now suggests that WBI may not be necessary and partial breast irradiation (PBI) may suffice. Chemotherapy combined with radiation has been shown to increase local control in BCT when compared to radiation alone. We hypothesize that women with ER negative early stage breast cancer treated with PBI and concurrently chemotherapy will have local control rates similar to women with ER positive disease. We initially proposed a randomized trial of PBI with sequential vs concurrent chemotherapy in women with ER (-) breast cancer status post lumpectomy and axillary nodal evaluation. But, to improve accrual the trial has been opened to include ER (+) breast cancer also.