Breast/Evaluation of Cryotherapy and TRPA1 Receptors in Chemotherapy Induced Neuropathy
This is a therapeutic study investigating the use of cryotherapy in the prevention of chemotherapy-induced peripheral neuropathy (CIPN) and associated nail toxicities. The therapeutic intervention will involve patients wearing an Elasto-Gel cold glove and sock on their non-dominant hand and foot. The dominant side will not have the glove and sock applied and will act as an internal control. The patients will wear the glove and sock during each infusion of taxane chemotherapy. Infusion therapy, assessments and patient questionnaires will take place in the Cancer Treatment and Research Center (CTRC) and the Electromyography Studies (EMG) will be performed at the Medical Arts and Research Center (MARC). The primary aim is to demonstrate if cryotherapy is a safe and effective intervention in preventing peripheral neuropathy and nail toxicity in patients receiving taxane chemotherapy. The secondary aim is evaluating the relation of CIPN with gene expression of TRPA1, TRPV1 and TRPM8.