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  • Preimplantation genetic testing (PGT)

Preimplantation genetic testing (PGT)

Preimplantation genetic testing (PGT)

Related to:Assisted Reproductive Technologies (ART)

Preimplantation genetic testing is a procedure offered in our center to help choose which embryo is the best to transfer. We utilize the latest technological advances and techniques. There are three different types of PGT available:

  1. Preimplantation genetic testing for aneuploidy (PGT-A) is offered to all patients undergoing ART to screen the embryo(s) for genetic abnormalities. This may help to reduce the risk of miscarriage and complications from pregnancy failure. The most common reason for a lack of success with IVF is aneuploidy within the embryo transferred. Aneuploidy refers to an abnormality in the number of chromosomes. This can be either extra chromosomes (such as in trisomy 21, Down’s Syndrome), missing chromosomes (monosomy X, Turner’s Syndrome), rearrangements of the chromosomes, or extra/missing smaller pieces of a chromosome.

PGT-A is not indicated for everyone. Randomized controlled trials have not demonstrated a benefit in improving live births in women under the age of 35 years. However, there are some clinical scenarios in which PGT-A could be beneficial and this could be discussed in greater detail with your physician if this applies to you.

  1. Preimplantation genetic testing for monogenic (single gene disorders, called PGT-M) is offered for those individuals who have or are carriers of specific genetic disorders. This may be recommended for individuals who are known to have a genetic mutation that could be passed along to their child. Some of the most common disorders are Cystic Fibrosis, Huntington’s disease, and inherited breast cancer genes. PGT-M could be recommended even in the absence of infertility when there is a high risk of having a child with a genetic disease.
  2. Preimplantation genetic testing for structural rearrangements (PGT-SR) is offered to parents who are known to have a chromosomal rearrangement (translocation or deletion/duplication) that may lead to recurrent pregnancy loss. Depending on the type of abnormality identified, a genetics counselor would be able to advise on the theoretical chances of having abnormal embryos.

For all types of PGT, several cells are removed from the embryo (commonly on day five of embryo development in our center) and sent for genetic analysis. Each biopsied embryo is then frozen (cryopreserved) until the results of the testing are available. The percentage of chromosomally normal embryos will vary from patient to patient and can be affected by many factors including age and the health history of both parents. An additional charge is required for preimplantation genetic testing.

Make an Appointment

For appointments or more information call (210) 450-4888.

UT Health Fertility Center doctors are also faculty at The University of Texas Health Science Center San Antonio School of Medicine. This allows us to remain one of the most cost-efficient fertility practices in the area. Our staff is happy to answer questions about referrals, itemized diagnostic and treatment costs and billing options. The UT Health Fertility Center participates in a variety of insurance plans. For your convenience, we accept VISA, MasterCard, and Discover.

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Physicians and care providers of UT Health San Antonio

8300 Floyd Curl Dr.
San Antonio, TX 78229

210-450-9000

 

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The University of Texas Health Science Center at San Antonio, also called UT Health San Antonio, is a leading academic health center with a mission to make lives better through excellence in advanced academics, life-saving research and comprehensive clinical care including health, dental and cancer services.

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