This multi-center exploratory clinical trial is a randomized trial designed to test whether a regenerative endodontic procedure using tissue engineering principles (REGENDO), or a revascularization (REVASC) endodontic procedure, in comparison to standard apexification treatment using a mineral trioxide aggregate barrier (apexification; APEX), produces a significantly better composite clinical outcome for the treatment of immature permanent teeth with pulpal necrosis.
Dr. Ken Hargreaves and Dr. Anibal Diogenes are well-known experts in the field of endodontics. Their past collaborations have lead to groundbreaking therapies, which have allowed pediatric patients to keep damaged teeth that would have otherwise had to be removed due to dental trauma.
This clinical trial is funded by a $1.7 million grant from the American Association of Endodontists Foundation. Additional support is supplied by the UT Health Science Center School of Dentistry.