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Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots
This multi-center exploratory clinical trial is a randomized trial designed to test whether a regenerative endodontic procedure using tissue engineering principles (REGENDO), or a revascularization (REVASC) endodontic procedure, in comparison to standard apexification treatment using a mineral trioxide aggregate barrier (apexification; APEX), produces a significantly better composite clinical outcome for the treatment of immature permanent teeth with pulpal necrosis.
Qualifications
- Is the participant between the ages of 6 and 20?
- Can you travel to one of the study locations (San Antonio, Texas; Baltimore, Maryland; Loma Linda, California) for treatment and follow-up?
- Does an endodontist consider the tooth in question restorable without the need of a stainless steel crown?
- Do you have access to a telephone and the ability to read and comprehend study materials in English or Spanish?
- Is there a legal guardian willing and able to provide informed consent?
Participating in this Study
- Choosing to participate in a study is an important personal decision.
- Talk with your doctor and family members or friends about deciding to join a study.
- To learn more about this study, you or your doctor may contact the study research staff.
- Please refer to this study by its ClinicalTrials.gov identifier: NCT01976065
About the Researchers
Dr. Ken Hargreaves and Dr. Anibal Diogenes are well-known experts in the field of endodontics. Their past collaborations have lead to groundbreaking therapies, which have allowed pediatric patients to keep damaged teeth that would have otherwise had to be removed due to dental trauma.
The American Association of Endodontists Foundation
This clinical trial is funded by a $1.7 million grant from the American Association of Endodontists Foundation. Additional support is supplied by the UT Health Science Center School of Dentistry.