Researchers in our labs are studying the roles and mechanism of the formation of bone, dentin, enamel and periodontium. We use transgenic and mutant mice to study the role of stem cells and differentiated cells in bones and teeth.
We develop unique in vitro cell models to study the stem cells that produce the bone, tooth dentin and all the components of the periosteum. We are developing epigenetic regulatory networks combined with deep gene expression analysis using next -generation sequencing methods combined with bioinformatics and computational analysis and modeling. From this knowledge database, we can predict new therapeutic approaches for corrected bone loss due to trauma and periodontium loss due to periodontal disease.
Oligodontia describes a condition when multiple teeth are missing. The affected teeth can include permanent molars, premolars and lateral incisors that are missing in the upper and lower arches. Gene mutations associated with oligodontia have been found in PAX9, MSX1, AXIN2, WNT10A and EDA. Affected persons need comprehensive multidisciplinary treatment.