Research is an important activity in the Department of Endodontics. Although our funded projects cover diverse topics, much of our efforts emphasize translational and basic science research projects that evaluate pain mechanisms.
These studies are facilitated by a group of basic scientists with diverse backgrounds and areas of expertise that work together as members of the Neuropharmacology Research Group to unravel the mystery of pain.
Even though TRPV1 has long been recognized as a key pain receptor, the endogenous substances responsible for its activation are not well understood. The Neuropharmacology Research Group has discovered that oxidized metabolites of linoleic acid (OLAMs), a common fatty acid found in cell membranes, represent a new class of endogenous substances that activate TRPV1.