Skip to main content

Part of UT Health San Antonio

School of Dentistry, UT Health San AntonioSchool of Dentistry, UT Health San Antonio

Part of UT Health San Antonio

Institutional Core Labs

  • iLabs
  • Bioanalytics & Single-Cell
  • Biospecimen and Translational Genomics
  • Flow Cytometry
  • Mass Spectometry
  • Optical Imaging
  • Structural Biology (NMR)
  • Structural Biology (X-Ray Crystallography)

Find a Researcher

  • Profiles

Research by School

  • Long School of Medicine
  • School of Dentistry
  • School of Health Professions
  • School of Nursing

Software Training & Cyberinfrastructure

  • VPR IT

Additional Resources

  • Environmental Health & Safety
  • Council of Principal Investigators
  • National Academy of Inventors
  • Office of Technology Commercialization
  • Postdoc Positions
  • Report A Discovery
  • Research Directory
  • San Antonio Bioscience Research
  • San Antonio Partnership for Precision Therapeutics
  • Spotlight on Research Integrity

Close Quicklinks

Menu
  • Home
  • About
  • Research Topics
  • Researchers
  • Clinical Trials
  • School of Dentistry
  • Patient Care

You are here

  • Home
  • Research
  • Dental Research
  • Clinical Trials
  • Regeneration of Pulp-Dentin Development
  • Clinical Trial Qualifications: Regeneration of Pulp Dentin Development

Clinical Trial Qualifications: Regeneration of Pulp Dentin Development

Inclusion Criteria

  • Age 6-20
  • Participant has a permanent tooth with a necrotic pulp (as defined by lack of responsiveness to both electrical pulp tests and cold [EndoIce] tests). If the tooth was traumatized, then pulpal necrosis is defined as either: 1) no response to both electrical pulp test and cold [EndoIce] test by three months after trauma, or 2) presence of a periapical lesion, or 3) radiographic evidence of root resorption, or 4) discoloration of the crown.
  • Tooth in question is restorable (as defined by Class A or Class B using Samet and Jotkowitz classification) without the need of a stainless steel crown.
  • Incomplete (i.e., immature) root development defined by apical foramen ≥1.0mm (each foramina >1.0mm for multi-rooted teeth).
  • At least 5 mm of root development (CEJ to radiographic apex).
  • Willing and able to provide informed assent/consent.
  • Legal guardian willing and able to provide informed consent.

Exclusion Criteria

  • No access to telephone for study contacts.
  • Unable to comprehend study materials in English or Spanish.
  • Subject not available for follow up at 12 or 24 months.
  • Previous allergic response to ciprofloxacin, metronidazole or minocycline or any materials used in the study.
  • History of systemic diseases with altered immune function including diabetes, immunodeficiency, leukemia, Addison's or Cushing's disease.
  • History of taking immunosuppressants or chemotherapeutic agents including glucocorticoids in the past 3 months.
  • Clinical or radiographic evidence of root fracture or alveolar fracture.
  • Tooth in question received prior endodontic obturation.
  • Tooth in question has class III mobility or dens invaginatus.
  • Tooth in question has a history of avulsion with extra-oral dry time longer than 1 hour.
  • Clinical judgement (with documentation of the reason)
  • Radiographic or clinical identification of ankylosis (replacement resorption) or inflammatory (infection-related) root resorption.

To Participate

Call UT Dentistry’s Advanced Endodontic Clinic at 210-567-3355.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01976065.

Map image of UT Health San Antonio location

Looking for Patient Care?

UT Health San Antonio
School of Dentistry

7703 Floyd Curl Drive
San Antonio, TX 78229

210-567-7000

  • Contact us
  • Maps & directions
  • Patient rights and responsibilities
  • Language assistance
  • Give a donation

We make lives better ®

The University of Texas Health Science Center at San Antonio, also called UT Health San Antonio, is a leading academic health center with a mission to make lives better through excellence in advanced academics, life-saving research and comprehensive clinical care including health, dental and cancer services.

Web Privacy | Links from websites affiliated with UT Health's website (uthscsa.edu) to other websites do not constitute or imply university endorsement of those sites, their content, or products and services associated with those sites. The content on this website is intended to be used for informational purposes only. Health information on this site is not meant to be used to diagnose or treat conditions. Consult a health care provider if you are in need of treatment.