Children are at risk for infections due to trauma or caries. Complete tooth development may take up to two years from the time a tooth has erupted. During this period, dental infections and subsequent dental loss have devastating long-term effects. Treatment options for young patients with infected teeth have been limited to traditional root canal treatments. Stem-cell based therapies represent a new treatment modality that promotes continued development and reestablishment of normal function.
Our research has focused on the identification of stem cells found in infected teeth in young patients and their therapeutic use. We have demonstrated that these cells can be delivered surgically during a regenerative endodontic procedure. This procedure allows for continued root development in addition to healing.
Up to 30%
of all children are affected by trauma to the permanent dentition.
with the application of stem-cell based therapies, addresses a previously unmet clinical need, promoting regeneration of tissues and function.
Dr. Anibal Diogenes is the principal investigator of a clinical trial evaluating the clinical outcomes of stem-cell based root canal therapies in young patients.
Learn about our ongoing clinical trial evaluating stem cell-based root canals.
Dr. Nikita Ruparel is an assistant professor member of the Regenerative Endodontics Trial Team.